Evidence map›Paper›PMID 29300776›Full record

ArticlePloS one2018

Prevalence of relative systemic hypertension in adults with sickle cell disease in Ghana.

Amma Benneh-Akwasi Kuma, Amma Twumwa Owusu-Ansah, Mary Akua Ampomah, Fredericka Sey, Edeghonghon Olayemi, Mehdi Nouraie, Solomon Fiifi Ofori-Acquah

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  4. Article
  5. Management of Kidney Disease with Sickle Cell Disease.Journal of the American Society of Nephrology : JASN · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Amma Benneh-Akwasi KumaDepartment of Hematology, College of Health Sciences, University of Ghana, Accra, Ghana.
Amma Twumwa Owusu-AnsahDivision of Hematology Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.ORCID 0000-0002-6476-0522
Mary Akua AmpomahGhana Institute of Clinical Genetics, Korle-Bu, Accra, Ghana.
Fredericka SeyGhana Institute of Clinical Genetics, Korle-Bu, Accra, Ghana.
Edeghonghon OlayemiDepartment of Hematology, College of Health Sciences, University of Ghana, Accra, Ghana.
Mehdi NouraieDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Heart, Lung and Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
Solomon Fiifi Ofori-AcquahDivision of Hematology Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.ORCID 0000-0001-5000-3048
University of Pittsburgh · USKorle Bu Teaching Hospital · GHUniversity of Ghana · GH

Funding

Cellular and Molecular Mechanisms of Acute Lung Injury in Sickle Cell DiseaseU01HL117721 · NHLBI · EMORY UNIVERSITY · PI DEBAUN, MICHAEL R., JOINER, CLINTON H · 2013 to 2017
$9.4M
Mechanisms of endothelial barrier phenotypes in sickle cell diseaseR01HL106192 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OFORI-ACQUAH, SOLOMON FIIFI · 2011 to 2016
$2.1M
NHLBI NIH HHS R01 HL106192NHLBI NIH HHS U01 HL117721NIH HHS R01HL106192NIH HHS R01HL106192S1NIH HHS U01HL117721
6 · The paper itself

Abstract

Individuals with sickle cell disease particularly with the homozygous (SS) genotype historically have relatively low blood pressure. Nonetheless, they develop vasculopathy-associated organ dysfunction and the risk of organ dysfunction increases at blood pressures that are normal in the general population. This phenomenon is termed relative systemic hypertension (RSH) with a systolic blood pressure range of 120-139 mmHg, and diastolic blood pressure range of 70-89 mmHg. The significance of RSH lies in its association with renal insufficiency, pulmonary hypertension, stroke and propensity to progress to systemic hypertension. We conducted a retrospective chart review of 1,000 adults with sickle cell disease at the Ghana Institute of Clinical Genetics, to determine the prevalence of RSH in sickle cell disease in Ghana and associated complications. We found a high prevalence of RSH and hypertension with a relatively low frequency of renal insufficiency. Pulse pressure, a predictor of mortality, was higher in males of all ages. We anticipate that providing an estimate of the burden of RSH will heighten its recognition and clinical management among health care providers.

Indexed as

AdolescentAdultAgedAged, 80 and overAnemia, Sickle CellFemaleGhanaHumansHypertensionMaleMiddle AgedPrevalenceYoung Adult

Identifiers

PMID29300776
PMCPMC5754083
OpenAlexW2782130367

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.