SynthesisPloS one2018
Optical coherence tomography for glaucoma diagnosis: An evidence based meta-analysis.
Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Diagnostic accuracy of teleretinal screening for detection of diabetic retinopathy and age-related macular degeneration: a systematic review and meta-analysis.BMJ open ophthalmology · 2022Pooled it
- Accuracy of optical coherence tomography for diagnosing glaucoma: an overview of systematic reviews.The British journal of ophthalmology · 2021Pooled it
- Changes of Peripapillary Retinal Nerve Fiber Layer in Childhood Glaucoma: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Diagnostic capability of ganglion cell complex thickness using spectral domain optical coherence tomography in glaucoma.BMC ophthalmology · 2026Observational
- The retinal nerve fibre layer thickness slope: a localised biomarker of the structure-function relationship in early glaucoma.The British journal of ophthalmology · 2026Article
- Explainable AI-driven diagnosis model for early glaucoma detection using grey-wolf optimized extreme learning machine approach.PLoS computational biology · 2026Article
- A comparative evaluation of parafoveal and perifoveal macular vessel density loss in glaucoma using 3 × 3 mm OCTA scans.Scientific reports · 2026Article
- Optical coherence tomography acquisition efficiency: comparison of Heidelberg spectralis OCT2 module & Zeiss Cirrus HD-OCT model 6000.Frontiers in ophthalmology · 2026Article
- Early Diagnosis of Glaucoma By Optical Coherence Tomography: A Systematic Review and Network Meta-analysis.Journal of ophthalmic & vision research · 2026Article
- Comparison of the diagnostic performance of two spectral-domain OCT machines in detecting glaucoma in high and non-high axial myopia eyes.International ophthalmology · 2025Article
- Evaluation of Ganglion Cell-Inner Plexiform Layer Thickness in the Diagnosis of Preperimetric and Early Perimetric Glaucoma.Journal of clinical medicine · 2025Article
- Establishment of Normative Retinal Nerve Fiber Layer Thickness in Healthy Koreans Using Huvitz Optical Coherence Tomography and Comparison with Cirrus OCT.Journal of clinical medicine · 2025Article
- Retinal imaging based glaucoma detection using modified pelican optimization based extreme learning machine.Scientific reports · 2024Article
- The OSCAR-MP Consensus Criteria for Quality Assessment of Retinal Optical Coherence Tomography Angiography.Neurology(R) neuroimmunology & neuroinflammation · 2023Review
- Improving OCT Image Segmentation of Retinal Layers by Utilizing a Machine Learning Based Multistage System of Stacked Multiscale Encoders and Decoders.Bioengineering (Basel, Switzerland) · 2023Article
- Glaucoma and Myopia: Diagnostic Challenges.Biomolecules · 2023Review
- Ganglion Cell Complex Analysis: Correlations with Retinal Nerve Fiber Layer on Optical Coherence Tomography.Diagnostics (Basel, Switzerland) · 2023Review
- Macular Vascularity and Ganglion Cell Complex Parameters in the Young Adults with Myopia and Progressive Myopia.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Effect of Conventional Cataract Surgery and Femtosecond Laser-Assisted Cataract Surgery on Bruch's Membrane Opening-Minimum Rim Width, Retinal Nerve Fiber Layer, and Macular Thickness.Journal of ophthalmology · 2023Article
- Birefringent Properties of the Peripapillary Retinal Nerve Fiber Layer in Healthy and Glaucoma Subjects Analyzed by Polarization-Sensitive OCT.Investigative ophthalmology & visual science · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEarly detection, monitoring and understanding of changes in the retina are central to the diagnosis of glaucomatous optic neuropathy, and vital to reduce visual loss from this progressive condition. The main objective of this investigation was to compare glaucoma diagnostic accuracy of commercially available optical coherence tomography (OCT) devices (Zeiss Stratus, Zeiss Cirrus, Heidelberg Spectralis and Optovue RTVue, and Topcon 3D-OCT). PATIENTS: 16,104 glaucomatous and 11,543 normal eyes reported in 150 studies.
methodsBetween Jan. 2017 and Feb 2017, MEDLINE®, EMBASE®, CINAHL®, Cochrane Library®, Web of Science®, and BIOSIS® were searched for studies assessing glaucoma diagnostic accuracy of the aforementioned OCT devices. Meta-analysis was performed pooling area under the receiver operating characteristic curve (AUROC) estimates for all devices, stratified by OCT type (RNFL, macula), and area imaged.
results150 studies with 16,104 glaucomatous and 11,543 normal control eyes were included. Key findings: AUROC of glaucoma diagnosis for RNFL average for all glaucoma patients was 0.897 (0.887-0.906, n = 16,782 patient eyes), for macula ganglion cell complex (GCC) was 0.885 (0.869-0.901, n = 4841 eyes), for macula ganglion cell inner plexiform layer (GCIPL) was 0.858 (0.835-0.880, n = 4211 eyes), and for total macular thickness was 0.795 (0.754-0.834, n = 1063 eyes).
conclusionThe classification capability was similar across all 5 OCT devices. More diagnostically favorable AUROCs were demonstrated in patients with increased glaucoma severity. Diagnostic accuracy of RNFL and segmented macular regions (GCIPL, GCC) scans were similar and higher than total macular thickness. This study provides a synthesis of contemporary evidence with features of robust inclusion criteria and large sample size. These findings may provide guidance to clinicians when navigating this rapidly evolving diagnostic area characterized by numerous options.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.