ArticlePloS one2018
Hemodynamics in a giant intracranial aneurysm characterized by in vitro 4D flow MRI.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Embolic Transport in LVAD Outflow: An Experimental Study Using Patient-Specific and Idealized Aortic Models.Annals of biomedical engineering · 2026Article
- Intraoperative hemispheric circulation time as a potential predictor of aneurysm occlusion after flow diverter treatment in large internal carotid artery aneurysm.Neurosurgical review · 2026Article
- Indefinite future of complex intracranial aneurysm underwent extracranial-intracranial bypass without aneurysm trapping: a pilot reports of 15 cases and hemodynamic analysis of 4D flow MRI.Neurosurgical review · 2026Article
- Hemodynamics in Cerebral Aneurysms and Parent Arteries With Incompletely Expanded Flow Diverter Stents.International journal for numerical methods in biomedical engineering · 2025Article
- Giant unruptured middle cerebral artery aneurysm revealed by intracranial hypertension: is a systematic decompressive hemicraniotomy mandatory?Neurosurgical review · 2024Article
- Development of idealized human aortic models forFrontiers in cardiovascular medicine · 2024Article
- Imaging of Intracranial Saccular Aneurysms.Stroke (Hoboken, N.J.) · 2023Review
- Design of a Patient-Specific Respiratory-Motion-Simulating Platform for In Vitro 4D Flow MRI.Annals of biomedical engineering · 2023Article
- A Novel Approach to Visualize Liquid Aluminum Flow to Advance Casting Science.Materials (Basel, Switzerland) · 2023Article
- On the numerical treatment of viscous and convective effects in relative pressure reconstruction methods.International journal for numerical methods in biomedical engineering · 2022Article
- Article
- SRflow: Deep learning based super-resolution of 4D-flow MRI data.Frontiers in artificial intelligence · 2022Article
- Role of patient-specific blood properties in computational fluid dynamics simulation of flow diverter deployed cerebral aneurysms.Technology and health care : official journal of the European Society for Engineering and Medicine · 2022Article
- A multi-modality approach for enhancing 4D flow magnetic resonance imaging via sparse representation.Journal of the Royal Society, Interface · 2022Article
- Self-Similar Functional Circuit Models of Arteries and Deterministic Fractal Operators: Theoretical Revelation for Biomimetic Materials.International journal of molecular sciences · 2021Article
- Hemodynamic Investigation of the Effectiveness of a Two Overlapping Flow Diverter Configuration for Cerebral Aneurysm Treatment.Bioengineering (Basel, Switzerland) · 2021Article
- Additive Fabrication of a Vascular 3D Phantom for Stereotactic Radiosurgery of Arteriovenous Malformations.3D printing and additive manufacturing · 2021Article
- Hemodynamics of Cerebral Aneurysms: Connecting Medical Imaging and Biomechanical Analysis.Annual review of biomedical engineering · 2020Review
- Custom tissue engineered aneurysm models with varying neck size and height for early stage in vitro testing of flow diverters.Journal of materials science. Materials in medicine · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental and computational data suggest that hemodynamics play a critical role in the development, growth, and rupture of cerebral aneurysms. The flow structure, especially in aneurysms with a large sac, is highly complex and three-dimensional. Therefore, volumetric and time-resolved measurements of the flow properties are crucial to fully characterize the hemodynamics. In this study, phase-contrast Magnetic Resonance Imaging is used to assess the fluid dynamics inside a 3D-printed replica of a giant intracranial aneurysm, whose hemodynamics was previously simulated by multiple research groups. The physiological inflow waveform is imposed in a flow circuit with realistic cardiovascular impedance. Measurements are acquired with sub-millimeter spatial resolution for 16 time steps over a cardiac cycle, allowing for the detailed reconstruction of the flow evolution. Moreover, the three-dimensional and time-resolved pressure distribution is calculated from the velocity field by integrating the fluid dynamics equations, and is validated against differential pressure measurements using precision transducers. The flow structure is characterized by vortical motions that persist within the aneurysm sac for most of the cardiac cycle. All the main flow statistics including velocity, vorticity, pressure, and wall shear stress suggest that the flow pattern is dictated by the aneurysm morphology and is largely independent of the pulsatility of the inflow, at least for the flow regimes investigated here. Comparisons are carried out with previous computational simulations that used the same geometry and inflow conditions, both in terms of cycle-averaged and systolic quantities.
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