ArticleThe journal of nutrition, health & aging2018
Association between Insulin-Like Growth Factor-1 and Frailty among Older Adults.
Article in The journal of nutrition, health & aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Exercise interventions and serum IGF-1 levels in older adults with frailty and/or sarcopenia: a systematic review and meta analysis.Frontiers in public health · 2025Pooled it
- How gait influences frailty models and health-related outcomes in clinical-based and population-based studies: a systematic review.Journal of cachexia, sarcopenia and muscle · 2021Pooled it
- Frailty before chronic disease: multisystem physiological differences in middle-aged adults from the UK Biobank.GeroScience · 2026Article
- A Cross-Sectional Analysis of Musculoskeletal and Functional Outcomes in Patients with Pituitary Disorders: Frailty and Sarcopenia.Journal of clinical medicine · 2026Article
- Immunosenescence as a driver of the transition from frailty to multimorbidity.Frontiers in immunology · 2026Review
- Two-year evolution of frailty status and predictive factors in Chinese older adults: a national longitudinal study.BMC geriatrics · 2025Article
- Musculoskeletal biomarkers in health and disease: implications for the aging spine-a review for spinal surgeons by the SRS adult spinal deformity task force on senescence.Spine deformity · 2025Review
- Cross-sectional association between brain-derived neurotrophic factor and intrinsic capacity in older adults: The mediating role of oxidative stress.The journal of nutrition, health & aging · 2025Article
- Plasma proteomic biomarkers of physical frailty in heart failure: a propensity score matched discovery-based pilot study.BMC cardiovascular disorders · 2025Article
- Advances in pathophysiology and assessment methods of chronic obstructive pulmonary disease with frailty.Chinese medical journal pulmonary and critical care medicine · 2025Review
- Aging and IGF-I: relationships with vitamin D and body composition. A mediation analysis.Frontiers in nutrition · 2025Article
- Scale-based screening and assessment of age-related frailty.Frontiers in public health · 2024Review
- Are Skeletal Muscle Changes during Prolonged Space Flights Similar to Those Experienced by Frail and Sarcopenic Older Adults?Life (Basel, Switzerland) · 2022Review
- Association between Bone-Related Physiological Substances and Oral Function in Community-Dwelling Older People.International journal of environmental research and public health · 2022Article
- Association between serum insulin-like growth factor 1 and locomotive syndrome in community-dwelling older people.BMC musculoskeletal disorders · 2022Article
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Association between insulin growth factor-1, bone mineral density, and frailty phenotype in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Article
- Mortality in malnourished older adults diagnosed by ESPEN and GLIM criteria in the SarcoPhAge study.Journal of cachexia, sarcopenia and muscle · 2020Article
- Nutrition Mediates the Relationship between Osteosarcopenia and Frailty: A Pathway Analysis.Nutrients · 2020Article
- Effects of Progressive Resistance Training on Cognition and IGF-1 Levels in Elder Women Who Live in Areas with High Air Pollution.International journal of environmental research and public health · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesFrailty is a course experienced in advanced aging. Identification of a biological factor associated with frailty is required. Although serum insulin-like growth factor-1 (IGF-1) is a potential factor related with frailty, consensus has not been reached regarding this relationship. This study aimed to investigate the association between IGF-1 and frailty in older adults.
designCross-sectional study.
settingCohort study that was part of the "National Center for Geriatrics and Gerontology - Study of Geriatric Syndromes."
participantsThe study participants were 4133 older adults (mean age, 71.8 ± 5.4 years). MEASUREMENTS: We assessed serum IGF-1 levels and frailty status and collected demographic variables, including cognitive function, as covariates.
resultsFrailty and pre-frailty were present in 274 subjects (7%) and 1930 subjects (47%), respectively. Subjects were divided into four groups based on quartiles of IGF-1 levels. Multinomial logistic analysis showed that the lowest group had significant odds of pre-frailty (crude model: odds ratio [OR] 1.58, 95% confidence interval [CI] 1.30-1.90, p < .001; adjusted model: OR 1.38, 95% CI 1.13-1.68, p = .002) and frailty (crude model: OR 3.42, 95% CI 2.38-4.92, p < .001; adjusted model: OR 1.54, 95% CI 1.02-2.32, p = .039), compared with the highest group.
conclusionLower serum IGF-1 levels were independently related with frailty in older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.