Trial reportThe journal of nutrition, health & aging2018
Effects of Low-Dose Dairy Protein Plus Micronutrient Supplementation during Resistance Exercise on Muscle Mass and Physical Performance in Older Adults: A Randomized, Controlled Trial.
Trial report in The journal of nutrition, health & aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 6 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- The impact of nutritional intervention and resistance training on muscle strength and mass in healthy older adults-a comparative analysis.Frontiers in nutrition · 2025Pooled it
- Pooled it
- Pooled it
- Effects of Milk Protein in Resistance Training-Induced Lean Mass Gains for Older Adults Aged ≥ 60 y: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- The Impact of Protein Supplementation on Appetite and Energy Intake in Healthy Older Adults: A Systematic Review with Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Nutritional Intervention to Prevent the Functional Decline in Community-Dwelling Older Adults: A Systematic Review.Nutrients · 2020Pooled it
- Biomarkers and the quadriceps femoris muscle architecture assessed by ultrasound in older adults with heart failure with preserved ejection fraction: a cross-sectional study.Aging clinical and experimental research · 2022Trial
- Trial
- The sarcopenia and physical frailty in older people: multi-component treatment strategies (SPRINTT) project: description and feasibility of a nutrition intervention in community-dwelling older Europeans.European geriatric medicine · 2021Trial
- Review
- Sarcopenia beyond muscle: endocrine-metabolic regulation and inter-tissue crosstalk across the muscle-tendon unit.Frontiers in endocrinology · 2026Review
- Current perspectives on sarcopenia: diagnosis and therapeutic approaches.The Korean journal of internal medicine · 2025Review
- The Impact of Nutritional Supplements on Sarcopenia: A Systematic Review and Meta-Analysis.Cureus · 2025Review
- Article
- Increasing Muscle Mass in Elders through Diet and Exercise: A Literature Review of Recent RCTs.Foods (Basel, Switzerland) · 2023Review
- Article
- New Therapeutic Approaches and Biomarkers for Increased Healthspan.Advances in experimental medicine and biology · 2021Review
- Article
- Animal source foods for the alleviation of double burden of malnutrition in countries undergoing nutrition transition.Animal frontiers : the review magazine of animal agriculture · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate whether supplementation with low-dose dairy protein plus micronutrients augments the effects of resistance exercise (RE) on muscle mass and physical performance compared with RE alone among older adults.
designRandomized controlled trial.
settingTokyo, Japan.
participantsEighty-two community-dwelling older adults (mean age, 73.5 years) were randomly allocated to an RE plus dairy protein and micronutrient supplementation group or an RE only group (n = 41 each).
interventionThe RE plus supplementation group participants ingested supplements with dairy protein (10.5 g/day) and micronutrients (8.0 mg zinc, 12 μg vitamin B12, 200 μg folic acid, 200 IU vitamin D, and others/day). Both groups performed the same twice-weekly RE program for 12 weeks. MEASUREMENTS: Whole-body, appendicular, and leg lean soft-tissue mass (WBLM, ALM, and LLM, respectively) with dual-energy X-ray absorptiometry, physical performance, biochemical characteristics, nutritional intake, and physical activity were measured before and after the intervention. Data were analyzed by using linear mixed-effects models.
resultsThe groups exhibited similar significant improvements in maximum gait speed, Timed Up-and-Go, and 5-repetition and 30-s chair stand tests. As compared with RE only, RE plus supplementation significantly increased WBLM (0.63 kg, 95% confidence interval [CI]: 0.31-0.95), ALM (0.37 kg, 95% CI: 0.16-0.58), LLM (0.27 kg, 95% CI: 0.10-0.46), and serum concentrations of 25-hydroxyvitamin D (4.7 ng/mL, 95% CI: 1.6-7.9), vitamin B12 (72.4 pg/mL, 95% CI: 12.9-131.9), and folic acid (12.9 ng/mL, 95% CI: 10.3-15.5) (all P < 0.05 for group-by-time interactions). Changes over time in physical activity and nutritional intake excluding the supplemented nutrients were similar between groups.
conclusionLow-dose dairy protein plus micronutrient supplementation during RE significantly increased muscle mass in older adults but did not further improve physical performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.