Evidence map›Paper›PMID 29300382›Full record

ArticleGenetics in medicine : official journal of the American College of Medical Genetics2018

Proposed outcomes measures for state public health genomic programs.

Debra Lochner Doyle, Mindy Clyne, Juan L Rodriguez, Deborah L Cragun, Laura Senier, Georgia Hurst, Kee Chan, David A Chambers

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Developing a genetic services assessment tool to inform quality improvement efforts in state genetic service delivery.Genetics in medicine : official journal of the American College of Medical Genetics · 2019
    Pooled it
  3. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Debra Lochner DoyleScreening and Genetics Unit, Washington State Department of Health, Kent, USA, Washington. Debra.LochnerDoyle@doh.wa.gov.
Mindy ClyneDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA.
Juan L RodriguezDivision of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Deborah L CragunCollege of Public Health, University of South Florida, Tampa, Florida, USA.
Laura SenierDepartment of Sociology & Anthropology and Department of Health Sciences, Northeastern University, Boston, Massachusetts, USA.
Georgia HurstI Have Lynch Syndrome, Inc., Evanston, Illinois, USA.
Kee ChanDepartment of Health Policy and Administration, School of Public Health, University of Illinois, Chicago, Illinois, USA.
David A ChambersDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA.
National Cancer Institute · USCenters for Disease Control and Prevention · USIllinois Department of Public Health · USNortheastern University · USUniversity of South Florida · USWashington State Department of Health · US

Funding

Barriers in Translating Genomic Research into State Public Health ProgramsK01HG006441 · NHGRI · UNIVERSITY OF WISCONSIN-MADISON · PI SENIER, LAURA · 2012 to 2016
$885k
NHGRI NIH HHS K01 HG006441
6 · The paper itself

Abstract

purposeTo assess the implementation of evidence-based genomic medicine and its population-level impact on health outcomes and to promote public health genetics interventions, in 2015 the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine formed an action collaborative, the Genomics and Public Health Action Collaborative (GPHAC). This group engaged key stakeholders from public/population health agencies, along with experts in the fields of health disparities, health literacy, implementation science, medical genetics, and patient advocacy.

methodsIn this paper, we present the efforts to identify performance objectives and outcome metrics. Specific attention is placed on measures related to hereditary breast ovarian cancer (HBOC) syndrome and Lynch syndrome (LS), two conditions with existing evidence-based genomic applications that can have immediate impact on morbidity and mortality.

resultsOur assessment revealed few existing outcome measures. Therefore, using an implementation research framework, 38 outcome measures were crafted.

conclusionEvidence-based public health requires outcome metrics, yet few exist for genomics. Therefore, we have proposed performance objectives that states might use and provided examples of a few state-level activities already under way, which are designed to collect outcome measures for HBOC and LS.

Indexed as

Colorectal Neoplasms, Hereditary NonpolyposisEvidence-Based MedicineGenomicsHumansNeoplastic Syndromes, HereditaryOutcome Assessment, Health CarePublic HealthPublic Health PracticeTreatment Outcomehereditary breast and ovarian cancerimplementation scienceLynch syndromeoutcome measurespublic health genomics

Identifiers

PMID29300382
PMCPMC6388766
OpenAlexW2782408328

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.