ArticleMolecules (Basel, Switzerland)2018
Synergistic Promotion on Tyrosinase Inhibition by Antioxidants.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 87 citations in OpenAlex.
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- Synergistic targeting of NF-κB by cinnamic and p-coumaric acids: computational and DPPH radical scavenging assessment.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Valorization ofPlants (Basel, Switzerland) · 2026Article
- Novel Tyrosinase and α-Glucosidase Inhibitors: 1,3-Bisbenzylphenylphenol and Congeners as Cosmetic Whitening Agents Based on Natural Products.Molecules (Basel, Switzerland) · 2026Article
- Dual-targeting antioxidant and anti-glycation strategy inhibits melanogenesis through clinical and mechanistic study.Scientific reports · 2025Article
- Quality Status and Skin-Related Functional Properties of Traditional Korean Fermented Vinegars.Foods (Basel, Switzerland) · 2025Article
- Current Findings onPlants (Basel, Switzerland) · 2025Review
- Tyrosinase Inhibitors Among Flora of Lubelskie Region-Application of Bio-Chromatographic Approach and Zebrafish Model in Bioactivity Screening of Plant Material.Molecules (Basel, Switzerland) · 2025Article
- Anilino-1,4-naphthoquinones as potent mushroom tyrosinase inhibitors:Journal of enzyme inhibition and medicinal chemistry · 2024Article
- Toxic Features and Metabolomic Intervention of Glabrene, an Impurity Found in the Pharmaceutical Product of Glabridin.International journal of molecular sciences · 2024Article
- Article
- Inhibitory Effects of Fermented Sprouted Oat Extracts on Oxidative Stress and Melanin Overproduction.Antioxidants (Basel, Switzerland) · 2024Article
- Synergistic impact of arbutin and kaempferol-7-O-α-L-rhamnopyranoside from Nephelium lappaceum L. on whitening efficacy and stability of cosmetic formulations.Scientific reports · 2023Article
- Synthesis,Journal of enzyme inhibition and medicinal chemistry · 2023Article
- Extracts from European Propolises as Potent Tyrosinase Inhibitors.Molecules (Basel, Switzerland) · 2022Article
- Phytochemical Composition and Biological Activities ofAntioxidants (Basel, Switzerland) · 2022Article
- Spleen-Targeted Glabridin-Loaded Nanoparticles Regulate Polarization of Monocyte/Macrophage (MAdvanced materials (Deerfield Beach, Fla.) · 2022Article
- Role of Phytochemicals in Skin PhotoprotectionFrontiers in pharmacology · 2022Review
- SOX9 in Keratinocytes Regulates Claudin 2 Transcription during Skin Aging.Contrast media & molecular imaging · 2022Article
- Insights on the Inhibitory Power of Flavonoids on Tyrosinase Activity: A Survey from 2016 to 2021.Molecules (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When exposed to ultraviolet radiation, the human skin produces profuse reactive oxygen species (ROS), which in turn activate a variety of biological responses. Mounting ROS levels activate tyrosinase by mobilizing α-melanocyte-stimulating hormone in the epidermis and finally stimulates the melanocytes to produce melanin. Meanwhile, the Keap1-Nrf2/ARE pathway, which removes ROS, is activated at increased ROS levels, and antioxidant compounds facilitates the dissociation of Nrf2. In this study, we explored the possible suppressing effects of antioxidant compounds and tyrosine inhibitors on melanin formation and the promotory effects of these compounds on ROS scavenging. The antioxidant activity of glabridin (GLA), resveratrol (RES), oxyresveratrol (OXYR), and phenylethylresorcinol (PR) were investigated via the stable free radical 2,2-diphenyl-1-picrylhydrazyl method. The inhibitory effects of the four compounds and their mixtures on tyrosinase were evaluated. l-Tyrosine or 3-(3,4-dihydroxyphenyl)-l-alanine (l-DOPA) was used as a substrate. The results showed that all mixtures did not exhibit synergistic effects with the l-tyrosine as a substrate, suggesting that l-tyrosine is not suitable as a substrate. However, the mixtures of "GLA:RES," "GLA:OXYR," "OXYR:RES," and "PR:RES" demonstrated synergistic effects (CI < 0.9,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.