Evidence map›Paper›PMID 29300354›Full record

ArticleMolecules (Basel, Switzerland)2018

Modulation of Inducible Nitric Oxide Synthase Expression in LPS-Stimulated BV-2 Microglia by Prenylated Chalcones from Cullen corylifolium (L.) Medik. through Inhibition of I-κBα Degradation.

Do Hee Kim, Hua Li, Yeong Eun Han, Ji Hye Jeong, Hwa Jin Lee, Jae-Ha Ryu

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 48 citations in OpenAlex.

  1. 2',4',6'-Trimethoxyacetophenone Isolated fromBiomolecules & therapeutics · 2025
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  5. In Vitro Anti-Inflammatory Effects ofPlants (Basel, Switzerland) · 2022
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  7. Antioxidants (Basel, Switzerland) · 2022
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Corylifol A fromInternational journal of molecular sciences · 2020
    Article
  17. Article
  18. Review
  19. Natural Chalcones in Chinese Materia Medica: Licorice.Evidence-based complementary and alternative medicine : eCAM · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Do Hee KimResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea. kdhkazan3@naver.com.
Hua LiResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea. cooldog227@hotmail.com.
Yeong Eun HanResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea. thddl1428@naver.com.
Ji Hye JeongResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea. jjh4415@naver.com.
Hwa Jin LeeDepartment of Natural Medicine Resources, Semyung University, Jecheon 27136, Korea. hwalee@semyung.ac.kr.
Jae-Ha RyuResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women's University, Seoul 04310, Korea. ryuha@sookmyung.ac.kr.
Sookmyung Women's University · KRSemyung University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The overproduction of nitric oxide (NO) and prostaglandin E₂ (PGE₂) by microglia may cause neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. From the activity-guided purification of

Indexed as

AnimalsCell LineChalconesCyclooxygenase 2DinoprostoneFabaceaeI-kappa B ProteinsLipopolysaccharidesMiceMicrogliaMolecular StructureNF-kappa BNitric Oxide Synthase Type IIPrenylationChalconesCyclooxygenase 2DinoprostoneI-kappa B ProteinsisobavachalconeLipopolysaccharidesNF-kappa BNitric Oxide Synthase Type IINos2 protein, mousePtgs2 protein, mouseCullen corylifoliuminducible nitric oxide synthaseinhibitory-κBαnitric oxideprenylated chalconeprostaglandin E2Psoralea corylifolia

Identifiers

PMID29300354
PMCPMC6017879
OpenAlexW2782419433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.