Evidence map›Paper›PMID 29300236›Full record

ArticleCritical care medicine2018

Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload.

Nareg H Roubinian, Jeanne E Hendrickson, Darrell J Triulzi, Jerome L Gottschall, Michael Michalkiewicz, Dhuly Chowdhury, Daryl J Kor, Mark R Looney, Michael A Matthay, Steven H Kleinman and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Transfusion-related lung complications are uncommon in non-ventilated liver failure patients undergoing low-volume plasma exchange.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Iatrogenic Decompensated Heart Failure.Current heart failure reports · 2020
    Review
  17. Article
  18. Article
  19. TACO and TRALI: biology, risk factors, and prevention strategies.Hematology. American Society of Hematology. Education Program · 2018
    Review
  20. The Pathogenic Involvement of Neutrophils in Acute Respiratory Distress Syndrome and Transfusion-Related Acute Lung Injury.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Nareg H RoubinianBlood Systems Research Institute, San Francisco, CA.
Jeanne E HendricksonDepartment of Laboratory Medicine, Yale University, New Haven, CT.
Darrell J TriulziDepartment of Pathology, Institute for Transfusion Medicine, Pittsburgh, PA.
Jerome L GottschallDepartment of Pathology, BloodCenter of Wisconsin, Milwaukee, WI.
Michael MichalkiewiczAurora Research Institute, Milwaukee, WI.
Dhuly ChowdhuryRTI International, Rockville, MD.
Daryl J KorDepartment of Anesthesia, Mayo Clinic, Rochester, MN.
Mark R LooneyDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA.
Michael A MatthayDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA.
Steven H KleinmanDepartment of Pathology and Laboratory Medicine, University of British Columbia, Victoria, BC, Canada.
Donald BrambillaRTI International, Rockville, MD.
Edward L MurphyBlood Systems Research Institute, San Francisco, CA.
National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)

Funding

NHLBI NIH HHS HHSN268201000002CNHLBI NIH HHS HHSN268201000003CNHLBI NIH HHS HHSN268201000004CNHLBI NIH HHS HHSN268201000005CNHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS L30 HL129355WHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

objectivesTransfusion-associated circulatory overload is characterized by hydrostatic pulmonary edema following blood transfusion. Restrictive transfusion practice may affect the occurrence and severity of transfusion-associated circulatory overload in critically ill patients. We sought to examine contemporary risk factors and outcomes for transfusion-associated circulatory overload.

designCase-control study.

settingFour tertiary care hospitals. PATIENTS: We prospectively enrolled 200 patients with transfusion-associated circulatory overload identified by active surveillance and 405 controls matched by transfusion intensity.

interventionsNone. MEASUREMENTS AND MAIN

resultsAmong 20,845 transfused patients who received 128,263 blood components from May 2015 until July 2016, transfusion-associated circulatory overload incidence was one case per 100 transfused patients. In addition to cardiovascular comorbidities, multivariable analysis identified the following independent predictors of transfusion-associated circulatory overload: acute kidney injury, emergency surgery, pretransfusion diuretic use, and plasma transfusion-the latter especially in females. Compared with matched controls, transfusion-associated circulatory overload cases were more likely to require mechanical ventilation (71% vs 49%; p < 0.001), experienced longer intensive care and hospital lengths of stay following transfusion, and had higher mortality (21% vs 11%; p = 0.02) even after adjustment for other potentially confounding variables.

conclusionsDespite restrictive transfusion practice, transfusion-associated circulatory overload remains a frequent complication of transfusion and is an independent risk factor for in-hospital morbidity and mortality. In addition to cardiovascular and renal risk factors, plasma transfusion was associated with transfusion-associated circulatory overload after controlling for other covariates. Additional research is needed to examine the benefit of reduced erythrocyte or plasma exposure in patients at high risk for transfusion-associated circulatory overload.

Indexed as

AgedAged, 80 and overCardiovascular DiseasesCase-Control StudiesCritical IllnessDiureticsFemaleHospital MortalityHumansKidney DiseasesMaleMiddle AgedPulmonary EdemaRisk FactorsSeverity of Illness IndexSex FactorsDiuretics

Identifiers

PMID29300236
PMCPMC5851817

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.