Evidence map›Paper›PMID 29299857›Full record

ArticleMolecular diversity2018

Synthesis and structure-activity relationship study of diaryl[d,f][1,3]diazepines as potential anti-cancer agents.

Longjia Yan, Hui Wang, Yunpeng Chen, Zhiwei Li, Yazhong Pei

Abstract read
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In one paragraph

Article in Molecular diversity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Design, synthesis andJournal of enzyme inhibition and medicinal chemistry · 2020
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Longjia YanThe Center for Combinatorial Chemistry and Drug Discovery, The College of Chemistry and The School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130012, Jilin, People's Republic of China. longjia.yan@yahoo.com.ORCID http://orcid.org/0000-0003-3703-6704
Hui WangThe Center for Combinatorial Chemistry and Drug Discovery, The College of Chemistry and The School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130012, Jilin, People's Republic of China.
Yunpeng ChenThe Center for Combinatorial Chemistry and Drug Discovery, The College of Chemistry and The School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130012, Jilin, People's Republic of China.
Zhiwei LiThe Center for Combinatorial Chemistry and Drug Discovery, The College of Chemistry and The School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130012, Jilin, People's Republic of China.
Yazhong PeiThe Center for Combinatorial Chemistry and Drug Discovery, The College of Chemistry and The School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130012, Jilin, People's Republic of China. peiyz@jlu.edu.cn.

Funding

Tang Aoqing Professorship research Tang Aoqing Professorship research grant from Jilin University
6 · The paper itself

Abstract

We herein report the synthesis, biological activity and preliminary structure-activity relationships of a series of diaryl[1,3]diazepines. These compounds were able to inhibit the proliferation of many cancer cell lines, such as HeLa, MCF-7, SGC7901 and A549. When HeLa cells were treated with lead compounds 7j and 7k at 3 [Formula: see text] concentration, cell arrest was observed in the G2/M phase.

Indexed as

Antineoplastic AgentsAzepinesChemistry Techniques, SyntheticHeLa CellsHumansStructure-Activity RelationshipAntineoplastic AgentsAzepinesAnti-cancer activityBenzo[13]diazepineDiaryl[][13]diazepineStructure–activity relationship

Identifiers

PMID29299857

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.