ReviewMolecular diversity2018
Malononitrile dimer as a privileged reactant in design and skeletal diverse synthesis of heterocyclic motifs.
Review in Molecular diversity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Defect-rich MOF-303 as a dual acid-base heterogeneous catalyst for the one-pot Biginelli synthesis of dihydropyrimidinones.Scientific reports · 2025Article
- Synthesis and Fluorescence Properties of Imidazopyridine-Linked Coumarins via Tandem C(spJournal of fluorescence · 2024Article
- Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles.Ultrasonics sonochemistry · 2024Review
- Article
- Synthesis and Aminomethylation of 2-Amino-4-(2-chlorophenyl)-6-(dicyanomethyl)-1,4-dihydropyridine-3,5-dicarbonitrileRussian journal of general chemistry · 2022Article
- Distinguishing drug/non-drug-like small molecules in drug discovery using deep belief network.Molecular diversity · 2021Article
- Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR.Green chemistry letters and reviews · 2021Article
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Authors and funding
2 authors.
Funding
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Abstract
Malononitrile dimer as a precursor reactant has been extensively applied in the diversity-oriented synthesis of various heterocyclic motifs, bis-heterocyclic compounds, fused heterocycle derivatives, bicyclic bridged heterocyclic scaffolds, and highly substituted carbocyclic compounds. These remarkable products were synthesized via various types of reactions, such as cycloaddition, cyclocondensation, cascade/domino/tandem reactions along with multi-component reactions. In addition, the flexibility and high reactivity of malononitrile dimer as a multi-functional reagent and its potential to the preparation of novel beneficial scaffolds as well as biologically active molecules signify it as a suitable building block in total synthesis, medicinal chemistry, and dyes. In the present review, the advances in the chemistry of malononitrile dimer as a potent reagent in organic synthesis have been reported in the past to now.
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Registered trials
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