Evidence map›Paper›PMID 29299800›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2017

Different effects of the immunostimulatory drug Stimforte on infections of hepatitis C virus and herpes simplex virus type 1.

D G Maldov, V L Andronova, S S Grigorian, E I Isaeva, P G Deryabin, D V Mishin, A A Balakina, A V Ilyichev, A A Terentyev, G A Galegov

Abstract read
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In one paragraph

Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. The Mechanism of the Stimforte Effect on the Activation of Target Cell Defense against Viral Infection.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

D G MaldovZAO SKY LTD, Moscow, Russia. maldov-dg@yandex.ru.
V L AndronovaGamaleya Institute of Epidemiology and Microbiology, Ministry of Health, Moscow, Russia.
S S GrigorianGamaleya Institute of Epidemiology and Microbiology, Ministry of Health, Moscow, Russia.
E I IsaevaGamaleya Institute of Epidemiology and Microbiology, Ministry of Health, Moscow, Russia.
P G DeryabinGamaleya Institute of Epidemiology and Microbiology, Ministry of Health, Moscow, Russia.
D V MishinGamaleya Institute of Epidemiology and Microbiology, Ministry of Health, Moscow, Russia.
A A BalakinaInstitute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.
A V IlyichevZAO SKY LTD, Moscow, Russia.
A A TerentyevInstitute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.
G A GalegovGamaleya Institute of Epidemiology and Microbiology, Ministry of Health, Moscow, Russia.
Ministry of Health of the Russian Federation · RUInstitute of Problems of Chemical Physics · RUYandex (Russia) · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stimforte, an immune response-stimulating preparation, is active with respect to hepatitis C virus (HCV) and herpes simplex virus type I (HSV-1). The effects of Stimforte in animals infected with either HCV or HSV-1 are fundamentally different. In mice with acute herpes virus infection, Stimforte administration leads to a higher activity of natural killer cells and cytotoxic lymphocytes, and the amount of interferon (IFN) λ grows. In mice infected with HCV, Stimforte administration results in a significant increase in IFN-β but not IFN-λ in blood and affected organs. Stimforte has been found to affect directly HCV reproduction that causes the infected cell death, but it does not affect HSV-1 reproduction in the Vero cells (V).

Indexed as

AnimalsAntiviral AgentsChlorocebus aethiopsHepacivirusHepatitis CHerpes SimplexHerpesvirus 1, HumanImmunologic FactorsInterferonsKiller Cells, NaturalMaleMiceMice, Inbred BALB CVero CellsVirus ReplicationAntiviral AgentsImmunologic FactorsInterferons

Identifiers

PMID29299800
OpenAlexW2781886349

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.