Evidence map›Paper›PMID 29299748›Full record

ArticleMolecular and cellular biochemistry2018

Association of COL4A1 (rs605143, rs565470) and CD14 (rs2569190) genes polymorphism with coronary artery disease.

Syed Tasleem Raza, Shania Abbas, Ale Eba, Fazal Karim, Irshad Ahmad Wani, Saliha Rizvi, Alina Zaidi, Farzana Mahdi

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Association ofThe International journal of angiology : official publication of the International College of Angiology, Inc · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. rs2569190A>G inJournal of cardiovascular development and disease · 2019
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Syed Tasleem RazaMolecular Biology Lab, Department of Biochemistry, Era's Lucknow Medical College and Hospital, Lucknow, UP, 226025, India. tasleem24@gmail.com.
Shania AbbasMolecular Biology Lab, Department of Biochemistry, Era's Lucknow Medical College and Hospital, Lucknow, UP, 226025, India.
Ale EbaMolecular Biology Lab, Department of Biochemistry, Era's Lucknow Medical College and Hospital, Lucknow, UP, 226025, India.
Fazal KarimDepartment of Cardiology, Era's Lucknow Medical College and Hospital, Lucknow, India.
Irshad Ahmad WaniDepartment of Cardiology, Era's Lucknow Medical College and Hospital, Lucknow, India.
Saliha RizviMolecular Biology Lab, Department of Biochemistry, Era's Lucknow Medical College and Hospital, Lucknow, UP, 226025, India.
Alina ZaidiMolecular Biology Lab, Department of Biochemistry, Era's Lucknow Medical College and Hospital, Lucknow, UP, 226025, India.
Farzana MahdiMolecular Biology Lab, Department of Biochemistry, Era's Lucknow Medical College and Hospital, Lucknow, UP, 226025, India.
Era's Lucknow Medical College and Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary artery disease (CAD) is the leading cause of death worldwide and it is basically caused by atherosclerosis. The atherosclerotic process includes complex events and each one involves a specific biological pathway and different genes. According to World Health Organization report, Cardiovascular diseases will be the largest cause of death and disability by 2020, with an estimated 2.6 million Indians predicted to die due to CAD predominantly with myocardial infarction. Genetic factors are estimated to contribute 30-60% of the CAD risk. The aim of this study is to investigate the association of COL4A1 and CD14 genes polymorphism with CAD. This study included 345 subjects, 185 CAD cases and 160 healthy controls. Single-nucleotide polymorphisms were evaluated by polymerase chain reaction and restriction fragment length polymorphism. Alleles and genotype frequencies between cases and controls were compared using χ

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdultAgedAtherosclerosisCase-Control StudiesCollagen Type IVCoronary Artery DiseaseGene FrequencyGenotypeHumansLipopolysaccharide ReceptorsMiddle AgedPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthCOL4A1 protein, humanCollagen Type IVLipopolysaccharide ReceptorsCADCD14COL4A1Gene polymorphism

Identifiers

PMID29299748
OpenAlexW2782155444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.