Evidence map›Paper›PMID 29299736›Full record

Trial reportEuropean journal of nutrition2019

The impact of probiotic supplementation during pregnancy on DNA methylation of obesity-related genes in mothers and their children.

Sanna Vähämiko, Asta Laiho, Riikka Lund, Erika Isolauri, Seppo Salminen, Kirsi Laitinen

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
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  13. Nutraceuticals in Pregnancy: A Special Focus on Probiotics.International journal of molecular sciences · 2024
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  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sanna VähämikoFunctional Foods Forum, Faculty of Medicine, University of Turku, 20014, Turku, Finland. sanvah@utu.fi.ORCID http://orcid.org/0000-0002-9201-6178
Asta LaihoTurku Centre for Biotechnology, University of Turku, 20520, Turku, Finland.
Riikka LundTurku Centre for Biotechnology, University of Turku, 20520, Turku, Finland.
Erika IsolauriDepartment of Clinical Medicine, Faculty of Medicine, University of Turku, 20014, Turku, Finland.
Seppo SalminenFunctional Foods Forum, Faculty of Medicine, University of Turku, 20014, Turku, Finland.
Kirsi LaitinenFaculty of Medicine, Institute of Biomedicine, University of Turku, 20014, Turku, Finland.
University of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDietary supplementation with probiotics during pregnancy has been suggested to decrease the risk for obesity in women after delivery and to minimize excessive weight gain in their children. Epigenetic DNA methylation has been proposed to impact on gene activity, thereby providing a plausible molecular mechanism for a broad range of biological processes and diseases. This pilot study aimed to evaluate whether probiotic supplementation during pregnancy could modify the DNA methylation status of the promoters of obesity and weight gain-related genes in mothers and their children.

methodsA sample of 15 pregnant women was taken from a prospective, randomized mother and infant nutrition and probiotic study. Seven women received the probiotic supplementation and eight served as controls. The women's and their children's DNA methylation status of obesity (623 genes) and weight gain-related (433) gene promoters were analyzed from blood samples at the mean of 9.8 months (range 6.1-12.7 months) postpartum.

resultsProbiotic supplementation led to significantly decreased levels of DNA methylation in 37 gene promoters and increased levels of DNA methylation in one gene promoter in women. In their children, 68 gene promoters were significantly affected consistently with a lower level of DNA methylation in the probiotic group.

conclusionsOn the basis of our pilot study, we suggest that probiotic supplementation during pregnancy may affect the DNA methylation status of certain promoters of obesity and weight gain-related genes both in mothers and their children, thereby providing a potential mechanism for long-lasting health effects.

Indexed as

Dietary SupplementsAdultDNA MethylationFemaleFinlandHumansInfantInfant, NewbornMaleMothersObesityPilot ProjectsPregnancyProbioticsProspective StudiesDietMethylationObesityPregnancyProbiotic

Identifiers

PMID29299736
OpenAlexW2782339709

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.