Evidence map›Paper›PMID 29299731›Full record

ReviewClinical oral investigations2018

MicroRNAs as effective surrogate biomarkers for early diagnosis of oral cancer.

Min Cao, Lijuan Zheng, Jianzhou Liu, Thomas Dobleman, Shen Hu, Vay Liang W Go, Ge Gao, Gary Guishan Xiao

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. MicroRNA-133 TargetsJournal of Cancer · 2021
    Article
  4. Article
  5. MicroRNA-31 Regulates Expression ofInternational journal of molecular sciences · 2020
    Article
  6. [Prognostic value of plasma miR-1290 expression in patients with oral squamous cell carcinoma].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Min CaoSchool of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian, 116024, China.
Lijuan ZhengGeriatric Department of Stomatology, Dalian Stomatology Hospital, Dalian, 116021, China.
Jianzhou LiuSchool of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian, 116024, China.
Thomas DoblemanGenomics and Functional Proteomics Laboratories, Creighton University Medical Center, Omaha, NE, 68131, USA.
Shen HuSchool of Dentistry, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Vay Liang W GoUCLA Agi Hirshberg Center for Pancreatic Diseases, David Geffen School of Medicine at University of California Los Angeles, 900 Veteran Avenue, Warren Hall 13-146, Los Angeles, CA, 90095-1786, USA.
Ge GaoFaculty of Laboratory Medicine, Xiangya Medical College of Central South University, Changsha, 410013, China.
Gary Guishan XiaoSchool of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian, 116024, China. gxiao@dlut.edu.cn.
University of California, Los Angeles · USDalian University of Technology · CNCentral South University · CNCHI Health Creighton University Medical Center - Bergan Mercy · USStomatology Hospital · CN

Funding

Faculty Startup Fund 2100874G05Hirshberg Foundation Award 1003082009NSFC 81642006
6 · The paper itself

Abstract

backgroundOral squamous cell carcinomas (OC) are life-threatening diseases emerging as major international health concerns.

objectiveDevelopment of an efficient clinical strategy for early diagnosis of the disease is a key for reducing the death rate. Biomarkers are proven to be an effective approach for clinical diagnosis of cancer. Although mechanisms underlying regulation of oral malignancy are still unclear, microRNAs (miRNAs) as a group of small non-coded RNAs may be developed as the effective biomarkers used for early detection of oral cancer.

methodsA literature search was conducted using the databases of PubMed, Web of Science, and the Cochrane Library. The following search terms were used: miRNAs and oral cancer or oral carcinoma. A critical appraisal of the included studies was performed with upregulated miRNAs and downregulated miRNAs in oral cancer.

resultsIn this review, we summarize the research progress made in miRNAs for diagnosis of oral cancer. The involvement of miRNAs identified in signal transduction pathways in OC, including Ras/MAPK signaling, PI3K/AKT signaling, JAK/STAT signaling, Wnt/β-catenin signaling, Notch signaling, and TGF-β/SMAD signaling pathway.

conclusionsA number of studies demonstrated that miRNAs may be developed as an ideal set of biomarkers used for early diagnosis and prognosis of cancers because of the stability in human peripheral blood and body fluids and availability of non-invasive approaches being developed for clinical utility. CLINICAL RELEVANCE: These findings suggest that miRNAs as biomarkers may be useful for diagnosis of OC.

Indexed as

Biomarkers, TumorEarly Detection of CancerHumansMicroRNAsMouth NeoplasmsBiomarkers, TumorMicroRNAsBiomarkersEarly diagnosismiRNA biologyOral cancerPathogenesis

Identifiers

PMID29299731
OpenAlexW2781748665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.