ArticleInternational journal of legal medicine2018
Proposals for best-quality immunohistochemical staining of paraffin-embedded brain tissue slides in forensics.
Article in International journal of legal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Immunohistochemical insights into hypothermia-related deaths: a systematic review.Forensic science, medicine, and pathology · 2025Pooled it
- Forensic neuropathology in the past decade: a scoping literature review.Forensic science, medicine, and pathology · 2024Article
- Differential HLA class I subunit (A, B, C heavy chain and βVirchows Archiv : an international journal of pathology · 2023Article
- GFAP positivity in neurons following traumatic brain injuries.International journal of legal medicine · 2021Article
- Myelin basic protein and neurofilament H in postmortem cerebrospinal fluid as surrogate markers of fatal traumatic brain injury.International journal of legal medicine · 2021Article
- miR-34a overexpression protects against hippocampal neuron damage caused by ketamine-induced anesthesia in immature rats through the Notch-1/NF-κB signaling pathway.American journal of translational research · 2021Article
- TMEM119 as a specific marker of microglia reaction in traumatic brain injury in postmortem examination.International journal of legal medicine · 2020Article
- Survival-time dependent increase in neuronal IL-6 and astroglial GFAP expression in fatally injured human brain tissue.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunohistochemistry (IHC) has become an integral part in forensic histopathology over the last decades. However, the underlying methods for IHC vary greatly depending on the institution, creating a lack of comparability. The aim of this study was to assess the optimal approach for different technical aspects of IHC, in order to improve and standardize this procedure. Therefore, qualitative results from manual and automatic IHC staining of brain samples were compared, as well as potential differences in suitability of common IHC glass slides. Further, possibilities of image digitalization and connected issues were investigated. In our study, automatic staining showed more consistent staining results, compared to manual staining procedures. Digitalization and digital post-processing facilitated direct analysis and analysis for reproducibility considerably. No differences were found for different commercially available microscopic glass slides regarding suitability of IHC brain researches, but a certain rate of tissue loss should be expected during the staining process.
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