ReviewLaryngoscope investigative otolaryngology2017
Models for the study of nasal and sinus physiology in health and disease: A review of the literature.
Review in Laryngoscope investigative otolaryngology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Induced Chronic Rhinosinusitis in Rats Leads to Secondary Changes in Sinonasal Microbiota.Laryngoscope investigative otolaryngology · 2025Article
- Study Models forMicroorganisms · 2025Review
- Effects of Probiotic Supplementation during Chronic Rhinosinusitis on the Microbiome.Journal of clinical medicine · 2024Review
- A Novel Model ofInternational journal of molecular sciences · 2024Article
- Host-microbe interactions in chronic rhinosinusitis biofilms and models for investigation.Biofilm · 2023Review
- Murine model for chronic rhinosinusitis: an interventional study.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2023Article
- Unraveling the role of the microbiome in chronic rhinosinusitis.The Journal of allergy and clinical immunology · 2022Review
- A novel anti-inflammatory treatment for bradykinin-induced sore throat or pharyngitis.Immunity, inflammation and disease · 2021Article
- Erythromycin reduces nasal inflammation by inhibiting immunoglobulin production, attenuating mucus secretion, and modulating cytokine expression.Scientific reports · 2021Article
- The impact of Sambucus nigra L. extract on inflammation, oxidative stress and tissue remodeling in a rat model of lipopolysaccharide-induced subacute rhinosinusitis.Inflammopharmacology · 2021Article
- Lactic acid bacteria as probiotics for the nose?Microbial biotechnology · 2021Review
- Evaluating inflammation in an obstruction-based chronic rhinosinusitis model in rabbits.International forum of allergy & rhinology · 2021Article
- A thermoresponsive hydrogel system for long-acting corticosteroid delivery into the paranasal sinuses.Journal of controlled release : official journal of the Controlled Release Society · 2021Article
- Gene Expression Profiles of Circular RNAs and MicroRNAs in Chronic Rhinosinusitis With Nasal Polyps.Frontiers in molecular biosciences · 2021Article
- Murine Model of Sinusitis Infection for Screening Antimicrobial and Immunomodulatory Therapies.Frontiers in cellular and infection microbiology · 2021Article
- The Microbiome and Chronic Rhinosinusitis.Immunology and allergy clinics of North America · 2020Review
- 3D Printed Biomimetic Rabbit Airway Simulation Model for Nasotracheal Intubation Training.Frontiers in veterinary science · 2020Article
- An optimized, robust and reproducible protocol to generate well-differentiated primary nasal epithelial models from extremely premature infants.Scientific reports · 2019Article
- Comparative models for human nasal infections and immunity.Developmental and comparative immunology · 2019Review
- Increased susceptibility of airway epithelial cells from ataxia-telangiectasia to S. pneumoniae infection due to oxidative damage and impaired innate immunity.Scientific reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Chronic sinusitis is a very common yet poorly understood medical condition with significant morbidity. Hence, it remains an entity that is difficult to treat with unsatisfactory outcomes of current management options. This necessitates research into the etiology and pathophysiology of the condition to enhance our knowledge and the therapeutic options. Unfortunately, this kind of research is not always feasible on human subjects due to practical and ethical limitations. Therefore, an alternative model that simulates the disease had to be found in order to overcome these limitations. These models could either be in vivo or in vitro. The aim of our review is to summarize the research findings and key discoveries of both in vivo and in vitro models of chronic sinusitis that have enhanced our understanding of the condition today and have paved the way for the future research of tomorrow. Methods: A review of the literature was conducted to identify the main successful in vivo and in vitro models for chronic sinusitis. Results: Creating a successful model for chronic sinusitis is no easy task. Over the years, both in vivo animal models and in vitro tissue culture models were proposed, with each model having its accolades and pitfalls, with the ideal model remaining elusive to this day. However, advancing three-dimensional cell culturing techniques seems to be a promising new way to find a more accurate model. Conclusion: None of the current models is perfect for a thorough study of chronic sinusitis. However, three-dimensional cell cultures have the potential to bridge the gap between in vivo and in vitro studies. Level of Evidence: NA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.