Evidence map›Paper›PMID 29299475›Full record

ArticleAnnals of translational medicine2017

Total knee arthroplasty fibrosis following arthroscopic intervention.

Jessica L Churchill, Nipun Sodhi, Anton Khlopas, Nicolas S Piuzzi, Sarah E Dalton, Morad Chughtai, Assem A Sultan, Steven Jones, Nick Williams, Peter M Bonutti and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Annals of translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. A meta-analysis of the therapeutic effect of total knee replacement after knee arthroscopic surgery.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025
    Pooled it
  3. Pooled it
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jessica L ChurchillDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, USA.
Nipun SodhiDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, USA.
Anton KhlopasDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, USA.
Nicolas S PiuzziDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, USA.
Sarah E DaltonDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, USA.
Morad ChughtaiDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, USA.
Assem A SultanDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, USA.
Steven JonesDepartment of Orthopaedic Surgery, Bonutti Clinic, Effingham, IL, USA.
Nick WilliamsDepartment of Orthopaedic Surgery, Bonutti Clinic, Effingham, IL, USA.
Peter M BonuttiDepartment of Orthopaedic Surgery, Bonutti Clinic, Effingham, IL, USA.
Michael A MontDepartment of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, USA.
Cleveland Clinic · USBonutti Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough arthroscopy is generally considered to be a relatively benign procedure with limited trauma to periarticular soft tissues, post-arthroscopic bleeding as well as osmolality differences between the normal saline used to irrigate and the native synovial fluid (282

methodsPrior to their total knee arthroplasty (TKA), 40 consecutive patients who had previously undergone arthroscopy were matched to 40 consecutive patients who had not. During each patient's TKA, a biopsy of the capsule and fat pad was taken and formalin sections were sent to pathology to assess for synovial thickness, cellularity, and the amount of fibrous tissue. The pathologist was blinded to the groupings. Findings for all histologic features were classified as equivocal, slight to moderate, and moderate to severe.

resultsThere were a significantly higher proportion of patients who had increased synovial thickness in the prior arthroscopy group as compared to the no-prior arthroscopy group (97.5%

conclusionsArthroscopic surgery may have long-term effects on capsular tissue as surgical observations of patients with prior arthroscopic surgery from this study found that the capsule is thicker and denser. Histologic assessment confirms there may be increased synovial thickness, increased cellularity, as well as thickening of fibrous tissue. This preliminary study and further evaluation are required. This suggests that arthroscopic surgery may have long-lasting effects on periarticular tissue especially the capsular tissue which may have implications for pain and functional recovery.

Indexed as

arthroscopyFibrosistotal knee arthroplasty (TKA)

Identifiers

PMID29299475
PMCPMC5750264
OpenAlexW2773983173

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.