ArticleIranian journal of basic medical sciences2017
Quetiapine reverses paclitaxel-induced neuropathic pain in mice: Role of alpha2- adrenergic receptors.
Article in Iranian journal of basic medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Evaluation and application analysis of animal models of PIPNP based on data mining.Open life sciences · 2025Review
- The mutual effect of progesterone and vitamin D in an animal model of peripheral nerve injury.Research in pharmaceutical sciences · 2024Article
- Anti-nociceptive effect of black seed oil on an animal model of chronic constriction injury.Research in pharmaceutical sciences · 2022Article
- Cyclovirobuxine D, a cardiovascular drug from traditional Chinese medicine, alleviates inflammatory and neuropathic pain mainlyFrontiers in pharmacology · 2022Article
- Preclinical and Clinical Evidence of Therapeutic Agents for Paclitaxel-Induced Peripheral Neuropathy.International journal of molecular sciences · 2021Review
- Effect of biotin supplementation on neuropathic pain induced by chronic constriction of the sciatic nerve in the rat.Research in pharmaceutical sciences · 2021Article
- Doxepin prevents the Expression and Development of Paclitaxel-Induced Neuropathic Pain.Advanced biomedical research · 2021Article
- Mitragynine, bioactive alkaloid of kratom, reduces chemotherapy-induced neuropathic pain in rats through α-adrenoceptor mechanism.Drug and alcohol dependence · 2020Article
- Antihyperalgesic Activity of Atomoxetine on Diabetes-Induced Neuropathic Pain: Contribution of Noradrenergic and Dopaminergic Systems.Molecules (Basel, Switzerland) · 2018Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPaclitaxel-induced peripheral neuropathy is a common adverse effect of cancer chemo -therapy. This neuropathy has a profound impact on quality of life and patient's survival. Preventing and treating paclitaxel-induced peripheral neuropathy is a major concern. First- and second-generation antipsychotics have shown analgesic effects both in humans and animals. Quetiapine is a novel atypical antipsychotic with low propensity to induce extrapyramidal or hyperprolactinemia side effects. The present study was designed to investigate the effects of quetiapine on the development and expression of neuropathic pain induced by paclitaxel in mice and the role of α MATERIALS AND
methodsPaclitaxel (2 mg/kg IP) was injected for five consecutive days which resulted in thermal hyperalgesia and mechanical and cold allodynia.
resultsEarly administration of quetiapine from the 1
conclusionThese results indicate that quetiapine, when administered after nerve injury can reverse the expression of neuropathic pain. Also, we conclude that α
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