ArticleOncotarget2017
Melatonin up-regulates the expression of the GATA-4 transcription factor and increases testosterone secretion from Leydig cells through RORα signaling in an
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- The influence and mechanism of gut microbiota on spermatogenesis.Cell biology and toxicology · 2026Review
- A review on the epigenetic regulation of testosterone synthesis in Leydig cells.Molecular and cellular biochemistry · 2025Review
- Ameliorative effect of Melatonin on 5-Fluorouracil-induced reproductive toxicity in male rats.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Article
- Short-Term Treatment of Melatonin Improves the Expression of Cell Adhesion Molecules in the Testis of the Mouse Cryptorchidism Model.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024Article
- The effect of biological mechanisms of melatonin on the proliferation of spermatogonial stem cells: a systematic review.Anatomy & cell biology · 2024Review
- Review
- Effect of Acute Melatonin Injection on Metabolomic and Testicular Artery Hemodynamic Changes and Circulating Hormones in Shiba Goats under Sub-Tropical Environmental Conditions.Animals : an open access journal from MDPI · 2023Article
- Effect of melatonin on steroidogenesis-related enzymes expression and testosterone synthesis following CoClIranian journal of basic medical sciences · 2023Article
- How does retinoic acid (RA) signaling pathway regulate spermatogenesis?Histology and histopathology · 2022Review
- Melatonin and the Programming of Stem Cells.International journal of molecular sciences · 2022Review
- ROR: Nuclear Receptor for Melatonin or Not?Molecules (Basel, Switzerland) · 2021Review
- Article
- Retinoid-related orphan nuclear receptor alpha (RORα)-deficient mice display morphological testicular defects.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- Melatonin Regulates the Synthesis of Steroid Hormones on Male Reproduction: A Review.Molecules (Basel, Switzerland) · 2018Review
- Insertion/Deletion Within the KDM6A Gene Is Significantly Associated With Litter Size in Goat.Frontiers in genetics · 2018Article
- Advancements in Spermatogenesis In Vitro: From Murine Success to Human Applications.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Because androgen function is regulated by its receptors, androgen-androgen receptor signaling is crucial for regulating spermatogenesis. Androgen is mainly testosterone secreted by testis. Based on the results of early studies in goats, the administration of melatonin over an extended period of time increases steroid production, but the underlying mechanism remains unclear. Here, we report the expression of the melatonin membrane receptors MT1 and MT2 and the retinoic acid receptor-related orphan receptor-alpha (RORα) in the goat testis. An
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.