Evidence map›Paper›PMID 29299140›Full record

ArticleOncotarget2017

MicroRNA-449a maintains self-renewal in liver cancer stem-like cells by targeting

Qianzhen Zhang, Zhi Yang, Juanjuan Shan, Limei Liu, Chungang Liu, Junjie Shen, Xuejiao Chen, Yanmin Xu, Jun Chen, Qinghua Ma and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Underexpression ofInternational journal of reproductive biomedicine · 2021
    Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Qianzhen Zhang *Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, 400044, China.
Zhi Yang *Center of Biological Therapy, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Juanjuan ShanCenter of Biological Therapy, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Limei LiuCenter of Biological Therapy, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Chungang LiuCenter of Biological Therapy, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Junjie ShenCenter of Biological Therapy, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Xuejiao ChenCenter of Biological Therapy, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Yanmin XuCenter of Biological Therapy, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Jun ChenCenter of Biological Therapy, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Qinghua MaCenter of Biological Therapy, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Li YangKey Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing, 400044, China.
Cheng QianCenter of Biological Therapy, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Army Medical University · CNChongqing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer stem cells (CSCs) are thought to be responsible for tumor invasion, metastasis, and recurrence. We previously showed that the pluripotency factor Nanog not only serves as a novel biomarker of CSCs but also potentially plays a crucial role in maintaining the self-renewal ability of liver CSCs. However, how CSCs maintain

Indexed as

cancer stem cellsMicroRNA-449aNanogself-renewalTCF3

Identifiers

PMID29299140
PMCPMC5746375
OpenAlexW2770646529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.