Evidence map›Paper›PMID 29299053›Full record

ArticleInfectious agents and cancer2017

Association of Epstein - Barr virus and breast cancer in Eritrea.

Ghimja Fessahaye, Ahmed M Elhassan, Elwaleed M Elamin, Ameera A M Adam, Anghesom Ghebremedhin, Muntaser E Ibrahim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious agents and cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Epstein-Barr Virus Infection and Increased Sporadic Breast Carcinoma Risk: A Meta-Analysis.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2020
    Pooled it
  3. Review
  4. The viral origins of breast cancer.Infectious agents and cancer · 2024
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Epstein-Barr Viral Infection and the Risk for Breast Cancer: A Systematic Review.International journal of hematology-oncology and stem cell research · 2023
    Review
  10. Observational
  11. Review
  12. Article
  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Ghimja FessahayeDepartment of Molecular Biology, Institute of Endemic Diseases, University of Khartoum, Al-Qasr Street, P.O. Box 102, Khartoum, Sudan.
Ahmed M ElhassanDepartment of Molecular Biology, Institute of Endemic Diseases, University of Khartoum, Al-Qasr Street, P.O. Box 102, Khartoum, Sudan.
Elwaleed M ElaminFaculty of Medical Laboratory Sciences, Alzaeim Alazhari University, Khartoum, Sudan.
Ameera A M AdamFaculty of Medical Laboratory Sciences, Department of Histopathology and Cytology, Al Neelain University, Khartoum, Sudan.
Anghesom GhebremedhinAsmera College of Health Sciences, Asmara, Eritrea.
Muntaser E IbrahimDepartment of Molecular Biology, Institute of Endemic Diseases, University of Khartoum, Al-Qasr Street, P.O. Box 102, Khartoum, Sudan.
University of Asmara · ERUniversity of Khartoum · SDAl-Neelain University · SDAlzaiem Alazhari University · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe oncogenic potential of Epstein-Barr virus (EBV) in breast cancer is being increasingly recognized. Despite some controversies regarding such role, new evidence is suggesting a culpability of EBV in breast cancer, particularly in Africa where the virus has been originally associated with causation of several solid and hematological malignancies. One example is a report from Sudan implicating EBV as a prime etiologic agent for an aggressive type of breast cancer, where nearly 100% of tumor tissues were shown to carry viral signatures. To get a broader view on such association, other nearby countries should be investigated. The present study aims to determine the prevalence and possible associations of the virus in Eritrean breast cancer patients.

methodsDetection of EBV genome using primers that target Epstein Barr Encoded RNA (EBER) gene and Latent Membrane Protein-1 (LMP-1) gene sequences was performed by polymerase chain reaction (PCR) on DNA samples extracted from 144 formalin fixed paraffin embedded breast cancer tissues and 63 non-cancerous breast tissue as control group. A subset of PCR positive samples was evaluated for EBER gene expression by in situ hybridization (ISH). Expression of Latent Membrane Protein-2a (LMP2a) was also assessed by immunohistochemistry in a subset of 45 samples.

resultsBased on PCR results, EBV genome signals were detected in a total of 40 samples (27.77%) as compared to controls (

conclusionsBased on these findings it can be concluded that EBV in Eritrea is associated with a smaller subset of tumors, unlike neighboring Sudan, thus pointing to possible differences in population predisposition and diseases epidemiology.

Indexed as

Breast cancerEpstein–Barr virusEritreaImmunohistochemistryin situ hybridizationPolymerase chain reaction

Identifiers

PMID29299053
PMCPMC5740847
OpenAlexW2779535340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.