ArticleNutrition & metabolism2017
The effects of vitamin D and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetes.
Article in Nutrition & metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 9 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Effects of vitamin D supplementation on glucose metabolism and pregnancy outcomes in GDM: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- The effect of omega-3 supplementation on metabolic, inflammatory and oxidative stress biomarkers in pregnant women: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2024Pooled it
- The effect of vitamin D supplementation on oxidative stress and inflammatory biomarkers in pregnant women: a systematic review and meta-analysis of clinical trials.BMC pregnancy and childbirth · 2022Pooled it
- The effects of vitamin and mineral supplementation on women with gestational diabetes mellitus.BMC endocrine disorders · 2021Pooled it
- Supplementation of Omega 3 during Pregnancy and the Risk of Preterm Birth: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Pooled it
- Vitamin D supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019Pooled it
- Omega-3 fatty acid addition during pregnancy.The Cochrane database of systematic reviews · 2018Pooled it
- The Impact of Short-Term Shark Liver Oil Supplementation on the Fatty Acid Composition of Erythrocyte Membranes.Nutrients · 2021Trial
- Effect of Vitamin D and ω-3 Fatty Acid Supplementation on Risk of Age-Related Macular Degeneration: An Ancillary Study of the VITAL Randomized Clinical Trial.JAMA ophthalmology · 2020Trial
- The Impact of Maternal Omega-3 Supplementation on Infant Anthropometric Measures and Pregnancy Outcomes: A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- An 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management.Journal of nutrition and metabolism · 2026Article
- Maternal Vitamin D Status, Oxidative Stress, and Implications for Neonatal Development: A Cross-Sectional Study.Metabolites · 2025Article
- Comparative Effects of Vitamin D Supplementation on Oxidative Stress in Relapsing-Remitting Multiple Sclerosis.Current issues in molecular biology · 2024Article
- Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis.Reproductive health · 2024Review
- Omega-3 fatty acid supplements and recurrent miscarriage: A perspective on potential mechanisms and clinical evidence.Food science & nutrition · 2023Review
- Markers of Oxidative Stress in Obstetrics and Gynaecology-A Systematic Literature Review.Antioxidants (Basel, Switzerland) · 2022Review
- Participant attrition and perinatal outcomes in prenatal vitamin D-supplemented gestational diabetes mellitus patients in Asia: A meta-analysis.World journal of methodology · 2022Article
- Choline and docosahexaenoic acid during the first 1000 days and children's health and development in low- and middle-income countries.Nutrition reviews · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study was carried out to determine the effects of vitamin D and omega-3 fatty acids co- supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes (GDM) patients.
methodsThis randomized, double-blind, placebo-controlled trial was conducted among 120 GDM women. Participants were randomly divided into four groups to receive: 1) 1000 mg omega-3 fatty acids containing 180 mg eicosapentaenoic acid (EPA) and 120 mg docosahexaenoic acid (DHA) twice a day + vitamin D placebo (
resultsSubjects who received vitamin D plus omega-3 fatty acids supplements compared with vitamin D, omega-3 fatty acids and placebo had significantly decreased high-sensitivity C-reactive protein (-2.0 ± 3.3 vs. -0.8 ± 4.4, -1.3 ± 2.4 and +0.9 ± 2.7 mg/L, respectively,
conclusionOverall, vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM women had beneficial effects on some biomarkers of inflammation, oxidative stress and pregnancy outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.