Evidence map›Paper›PMID 29299040›Full record

ReviewNutrition & metabolism2017

The metabolism and significance of homocysteine in nutrition and health.

Avinash Kumar, Henry A Palfrey, Rashmi Pathak, Philip J Kadowitz, Thomas W Gettys, Subramanyam N Murthy

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrition & metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04515095 (A Safety and Feasibility Study of Water-only Fasting and Refeeding for Treatment of Stage 1 and 2 Hypertensive Patients), which is not on this map. Cited by 171 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed, 10 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04515095 nacompletednot on this mapstarted 2020, after this paper: background citation

A Safety and Feasibility Study of Water-only Fasting and Refeeding for Treatment of Stage 1 and 2 Hypertensive Patients

TypeinterventionalSponsorTrueNorth Health FoundationRan2020 to 2022Enrolled30ConditionsHypertensionArmsWater-only Fasting
3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 10 syntheses or guidelines pooled it, 362 citations in OpenAlex.

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  17. Paraoxonase 2 as a target for aging-related diseases.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026
    Review
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111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Avinash KumarEnvironmental Toxicology Department, Southern University and A&M College, Baton Rouge, LA 70813 USA.
Henry A PalfreyEnvironmental Toxicology Department, Southern University and A&M College, Baton Rouge, LA 70813 USA.
Rashmi PathakEnvironmental Toxicology Department, Southern University and A&M College, Baton Rouge, LA 70813 USA.
Philip J KadowitzDepartment of Pharmacology, Tulane University School of Medicine, New Orleans, LA USA.
Thomas W GettysLaboratory of Nutrient Sensing and Adipocyte Signaling, Pennington Biomedical Research Center, Baton Rouge, LA USA.
Subramanyam N MurthyEnvironmental Toxicology Department, Southern University and A&M College, Baton Rouge, LA 70813 USA.ORCID 0000-0002-9337-329X
Southern University and Agricultural and Mechanical College · USPennington Biomedical Research Center · USTulane University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in 1969. Hcy is a sulfur containing amino acid derived from the essential amino acid methionine (Met). Hyperhomocysteinemia (HHcy) was subsequently shown in several age-related pathologies such as osteoporosis, Alzheimer's disease, Parkinson's disease, stroke, and cardiovascular disease (CVD). Also, Hcy is associated with (but not limited to) cancer, aortic aneurysm, hypothyroidism and end renal stage disease to mention some. The circulating levels of Hcy can be increased by defects in enzymes of the metabolism of Met, deficiencies of vitamins B

Indexed as

Cardiovascular diseaseDietaryHomocysteineHyperhomocysteinemiaInflammationMethionine

Identifiers

PMID29299040
PMCPMC5741875
OpenAlexW2777631080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.