ArticleNature communications2018
Redox regulation of PEP activity during seedling establishment in Arabidopsis thaliana.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 70 citations in OpenAlex.
- Turning over a green leaf: integrating light signals toward chloroplast establishment.Plant physiology · 2026Review
- A red/blue optoswitch for temporal control of chloroplast transcription and biogenesis in Arabidopsis.Nature communications · 2026Article
- Map-based cloning identifies a missense SNP in CsTRX z, encoding a z-type thioredoxin homolog, as the genetic determinant of Dominant Virescent Leaf in cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- OsPRDA1 Interacts With OsFSD2 To Promote Chloroplast Development by Regulating Chloroplast Gene Expression in Rice.Rice (New York, N.Y.) · 2025Article
- RAS, a Pentatricopeptide Repeat Protein, Interacts with OsTRX z to Regulate Chloroplast Gene Transcription and RNA Processing.Plants (Basel, Switzerland) · 2025Article
- De-etiolation is Almost Color Blind: The Study of Photosynthesis Awakening under Blue and Red Light.Plant & cell physiology · 2024Article
- Antioxidant Responses and Redox Regulation Within Plant-Beneficial Microbe Interaction.Antioxidants (Basel, Switzerland) · 2024Review
- Architecture of the spinach plastid-encoded RNA polymerase.Nature communications · 2024Article
- WHIRLY proteins, multi-layer regulators linking the nucleus and organelles in developmental and stress-induced senescence of plants.Annals of botany · 2024Review
- Divergent Protein Redox Dynamics and Their Relationship with Electron Transport Efficiency during Photosynthesis Induction.Plant & cell physiology · 2024Article
- Redox regulation, thioredoxins, and glutaredoxins in retrograde signalling and gene transcription.Journal of experimental botany · 2023Review
- Chloroplast gene expression: Recent advances and perspectives.Plant communications · 2023Review
- Current Insights into the Redox Regulation Network in Plant Chloroplasts.Plant & cell physiology · 2023Review
- Article
- Low-temperature and circadian signals are integrated by the sigma factor SIG5.Nature plants · 2023Article
- Tetrapyrrole biosynthesis pathway regulates plastid-to-nucleus signaling by controlling plastid gene expression in plants.Plant communications · 2023Article
- Thioredoxins m regulate plastid glucose-6-phosphate dehydrogenase activity in Arabidopsis roots under salt stress.Frontiers in plant science · 2023Article
- Role of plastids and mitochondria in the early development of seedlings in dark growth conditions.Frontiers in plant science · 2023Review
- Correlated retrograde and developmental regulons implicate multiple retrograde signals as coordinators of chloroplast development in maize.The Plant cell · 2022Article
- OsWHY1 Interacts with OsTRX z and is Essential for Early Chloroplast Development in Rice.Rice (New York, N.Y.) · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of the plastid-encoded RNA polymerase is tightly controlled and involves a network of phosphorylation and, as yet unidentified, thiol-mediated events. Here, we characterize PLASTID REDOX INSENSITIVE2, a redox-regulated protein required for full PEP-driven transcription. PRIN2 dimers can be reduced into the active monomeric form by thioredoxins through reduction of a disulfide bond. Exposure to light increases the ratio between the monomeric and dimeric forms of PRIN2. Complementation of prin2-2 with different PRIN2 protein variants demonstrates that the monomer is required for light-activated PEP-dependent transcription and that expression of the nuclear-encoded photosynthesis genes is linked to the activity of PEP. Activation of PEP during chloroplast development likely is the source of a retrograde signal that promotes nuclear LHCB expression. Thus, regulation of PRIN2 is the thiol-mediated mechanism required for full PEP activity, with PRIN2 monomerization via reduction by TRXs providing a mechanistic link between photosynthetic electron transport and activation of photosynthetic gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.