ArticleProceedings of the National Academy of Sciences of the United States of America2018
Transient visual pathway critical for normal development of primate grasping behavior.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed.
- Functional ultrasound imaging reveals early pathway-specific reorganization of central visual circuits in a mouse model of Batten disease.Neurobiology of disease · 2026Article
- From error to evidence: blindsight in the making†.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Early-life medial pulvinar disruption drives schizophrenia-relevant prefrontal inhibitory and cognitive deficits in primates.bioRxiv : the preprint server for biology · 2026Article
- Functional ultrasound imaging reveals pathway-specific visual system reorganization in youngbioRxiv : the preprint server for biology · 2026Article
- Early Development of Direction Selectivity in the Higher Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Widespread Corticothalamic Connectivity Identifies the Inferior Pulvinar as a Central Node in Visual Network Architecture.bioRxiv : the preprint server for biology · 2026Article
- Processing of natural scenes in the human pulvinar.Nature communications · 2025Article
- Projection Motifs and Wiring Logic of Medial Pulvinar Thalamocortical Axons in the Marmoset Monkey.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Optic ataxia in patients with thalamic lesions.Brain communications · 2025Article
- Development of Higher-Level Vision: A Network Perspective.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Time course of recovery of different motor functions following a reproducible cortical infarction in non-human primates.Frontiers in neurology · 2023Article
- Unilateral resection of both cortical visual pathways in a pediatric patient alters action but not perception.Neuropsychologia · 2022Article
- The nature of blindsight: implications for current theories of consciousness.Neuroscience of consciousness · 2022Review
- Retinal ganglion cells projecting to superior colliculus and pulvinar in marmoset.Brain structure & function · 2021Article
- Visual Cortical Area MT Is Required for Development of the Dorsal Stream and Associated Visuomotor Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Presence of the Endocannabinoid System in the Inferior Pulvinar of the Vervet Monkey.Brain sciences · 2021Article
- Cellular-resolution gene expression profiling in the neonatal marmoset brain reveals dynamic species- and region-specific differences.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Immunoreactivity of Vesicular Glutamate Transporter 2 Corresponds to Cytochrome Oxidase-Rich Subcompartments in the Visual Cortex of Squirrel Monkeys.Frontiers in neuroanatomy · 2021Article
- The postnatal development of MT, V1, LGN, pulvinar and SC in prosimian galagos (Otolemur garnettii).The Journal of comparative neurology · 2020Article
- V1-bypassing thalamo-cortical visual circuits in blindsight and developmental dyslexia.Current opinion in physiology · 2020Article
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Abstract
An evolutionary hallmark of anthropoid primates, including humans, is the use of vision to guide precise manual movements. These behaviors are reliant on a specialized visual input to the posterior parietal cortex. Here, we show that normal primate reaching-and-grasping behavior depends critically on a visual pathway through the thalamic pulvinar, which is thought to relay information to the middle temporal (MT) area during early life and then swiftly withdraws. Small MRI-guided lesions to a subdivision of the inferior pulvinar subnucleus (PIm) in the infant marmoset monkey led to permanent deficits in reaching-and-grasping behavior in the adult. This functional loss coincided with the abnormal anatomical development of multiple cortical areas responsible for the guidance of actions. Our study reveals that the transient retino-pulvinar-MT pathway underpins the development of visually guided manual behaviors in primates that are crucial for interacting with complex features in the environment.
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