Trial reportScience translational medicine2018
Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans.
Trial report in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- Neuromodulation for Subjective Tinnitus: A Systematic Review and Meta-Analysis of Randomized Trials.The Laryngoscope · 2026Pooled it
- Guideline
- Bimodal Stimulation of the Auditory-Somatosensory System Improves Auditory Sensory Gating Function in Patients with Tinnitus.Journal of the American Academy of Audiology · 2026Trial
- Reversing Synchronized Brain Circuits Using Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts: A Randomized Clinical Trial.JAMA network open · 2023Trial
- Trigeminal Nerve Stimulation for Disorders of Consciousness: A Narrative Review of Potential Mechanisms, Clinical Evidence, and Future Perspectives.CNS neuroscience & therapeutics · 2026Review
- Auditory Network Discoherence in Chronic Tinnitus.medRxiv : the preprint server for health sciences · 2026Article
- From Physical Replacement to Biological Symbiosis: Evolutionary Paradigms and Future Prospects of Auditory Reconstruction Brain-Computer Interfaces.Micromachines · 2026Review
- Inhibition of Cortical Evoked Responses to Sound Pulses by Preceding Silent Gaps.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Theta-Beta/Gamma Coupling Identifies Bothersome Tinnitus Induced by Thalamocortical Dysrhythmia.Brain and behavior · 2025Article
- Reducing Tinnitus via Inhibitory Influence of the Sensorimotor System on Auditory Cortical Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Reversing Cochlear Nucleus Maladaptive Plasticity via Customized Extracochlear Stimulation: A New Approach for Tinnitus Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Unravelling the Silence: Exploring Tinnitus Pathophysiology and the Promise of Traditional Chinese Medicine.International journal of general medicine · 2025Review
- The Current State of Tinnitus Diagnosis and Treatment: a Multidisciplinary Expert Perspective.Journal of the Association for Research in Otolaryngology : JARO · 2024Review
- Optimization of the Operant Silent Gap-in-Noise Detection Paradigm in Humans.Journal of integrative neuroscience · 2024Observational
- Combining sound with tongue stimulation for the treatment of tinnitus: a multi-site single-arm controlled pivotal trial.Nature communications · 2024Article
- Tinnitus: Clinical Insights in Its Pathophysiology-A Perspective.Journal of the Association for Research in Otolaryngology : JARO · 2024Review
- Cross-Modal Tinnitus Remediation: A Tentative Theoretical Framework.Brain sciences · 2024Article
- Bi-sensory stimulation as a treatment option for somatic tinnitus.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Current and Emerging Therapies for Chronic Subjective Tinnitus.Journal of clinical medicine · 2023Review
- Somatosensory Tinnitus: Recent Developments in Diagnosis and Treatment.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The dorsal cochlear nucleus is the first site of multisensory convergence in mammalian auditory pathways. Principal output neurons, the fusiform cells, integrate auditory nerve inputs from the cochlea with somatosensory inputs from the head and neck. In previous work, we developed a guinea pig model of tinnitus induced by noise exposure and showed that the fusiform cells in these animals exhibited increased spontaneous activity and cross-unit synchrony, which are physiological correlates of tinnitus. We delivered repeated bimodal auditory-somatosensory stimulation to the dorsal cochlear nucleus of guinea pigs with tinnitus, choosing a stimulus interval known to induce long-term depression (LTD). Twenty minutes per day of LTD-inducing bimodal (but not unimodal) stimulation reduced physiological and behavioral evidence of tinnitus in the guinea pigs after 25 days. Next, we applied the same bimodal treatment to 20 human subjects with tinnitus using a double-blinded, sham-controlled, crossover study. Twenty-eight days of LTD-inducing bimodal stimulation reduced tinnitus loudness and intrusiveness. Unimodal auditory stimulation did not deliver either benefit. Bimodal auditory-somatosensory stimulation that induces LTD in the dorsal cochlear nucleus may hold promise for suppressing chronic tinnitus, which reduces quality of life for millions of tinnitus sufferers worldwide.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.