Evidence map›Paper›PMID 29298844›Full record

ArticleEndocrine connections2018

A six-gene panel to label follicular adenoma, low- and high-risk follicular thyroid carcinoma.

Anello Marcello Poma, Riccardo Giannini, Paolo Piaggi, Clara Ugolini, Gabriele Materazzi, Paolo Miccoli, Paolo Vitti, Fulvio Basolo

Open access · goldAbstract read
In one paragraph

Article in Endocrine connections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
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  9. Oncotarget · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Anello Marcello PomaDepartment of SurgicalMedical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Riccardo GianniniDepartment of SurgicalMedical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Paolo PiaggiNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of Health, Phoenix, Arizona, USA.
Clara UgoliniDepartment of Laboratory MedicineSection of Pathology, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Gabriele MaterazziDepartment of SurgicalMedical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Paolo MiccoliDepartment of SurgicalMedical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Paolo VittiDepartment of Clinical and Experimental MedicineUniversity of Pisa, Pisa, Italy.
Fulvio BasoloDepartment of SurgicalMedical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy fulvio.basolo@med.unipi.it.
University of Pisa · ITAzienda Ospedaliera Universitaria Pisana · ITNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The distinction between follicular thyroid carcinomas (FTCs) and follicular-patterned benign lesions is almost impossible on fine-needle aspiration cytology. Furthermore, minimally invasive FTCs (MI-FTCs) with less than 4 vascular invasion foci generally have an excellent prognosis, but there are exceptions and, so far, no molecular marker appears able to identify them reliably. We aimed to distinguish benign lesions from low- and high-risk FTCs by a small-scale combination of genes. The expression analysis of 75 selected genes was performed on 18 follicular adenomas (FAs), 14 MI-FTCs and 6 widely invasive FTC (WI-FTCs). The mutational status of the

Indexed as

biomarkerfollicular thyroid carcinomaFTCgene expressionminimally invasive

Identifiers

PMID29298844
PMCPMC5754511
OpenAlexW2781886380

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.