ArticleLipids in health and disease2018
Persistently high psychological well-being predicts better HDL cholesterol and triglyceride levels: findings from the midlife in the U.S. (MIDUS) longitudinal study.
Article in Lipids in health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 110 citations in OpenAlex.
- Community-Based Evaluation of the Associations Between Well-Being and Cardiovascular Disease Risk.Journal of the American Heart Association · 2022Trial
- Lower HDL-cholesterol, a known marker of cardiovascular risk, was associated with depression in type 1 diabetes: a cross sectional study.Lipids in health and disease · 2019Trial
- The association of environmental mastery and diabetes distress among young adults with type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2025Article
- Association between uric acid/high-density lipoprotein cholesterol ratio and testosterone deficiency in adult American men: findings from the national health and nutrition examination survey 2011-2016.BMC public health · 2025Article
- The association between metabolite concentrations and wellbeing in adults.Scientific reports · 2025Article
- Dynamics of HDL-Cholesterol Following a Post-Myocardial Infarction Cardiac Rehabilitation Program.Reviews in cardiovascular medicine · 2025Article
- Are there sociodemographic-specific associations of coping with heart disease and diabetes incidence?Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Article
- Relationship between Ikigai and longitudinal changes in serum HDL cholesterol levels: the Circulatory Risk in Communities Study (CIRCS).Lipids in health and disease · 2024Article
- Contributions of Eudaimonic Well-Being to Mental Health Practice.Mental health and social inclusion · 2023Article
- High S100B Levels Predict Antidepressant Response in Patients With Major Depression Even When Considering Inflammatory and Metabolic Markers.The international journal of neuropsychopharmacology · 2022Article
- The Cardiovascular Cost of Silence: Relationships Between Self-silencing and Carotid Atherosclerosis in Midlife Women.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2022Article
- Optimism and Lipid Profiles in Midlife: A 15-Year Study of Black and White Adults.American journal of preventive medicine · 2022Article
- Is more, better? Relationships of multiple psychological well-being facets with cardiometabolic disease.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2022Article
- Psychological resilience predicting cardiometabolic conditions in adulthood in the Midlife in the United States Study.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Association between serum sphingolipids and eudaimonic well-being in white U.S. adults.Scientific reports · 2021Article
- Positive psychological well-being and cardiovascular disease: Exploring mechanistic and developmental pathways.Social and personality psychology compass · 2021Article
- Linking Amygdala Persistence to Real-World Emotional Experience and Psychological Well-Being.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Mediterranean Lifestyle to Promote Physical, Mental, and Environmental Health: The Case of Chile.International journal of environmental research and public health · 2020Review
- Sense of Purpose in Life and Cardiovascular Disease: Underlying Mechanisms and Future Directions.Current cardiology reports · 2019Review
- Longitudinal Profiles of Psychological Well-Being and Health: Findings From Japan.Frontiers in psychology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPsychological correlates of blood lipid levels have been previously evaluated mostly in cross sectional studies. However, prospectively measured psychological factors might also predict favorable blood lipid profiles, thereby indicating a healthy mind/body interplay that is associated with less disease, better health and longer lives.
methodsThis paper examined whether longitudinal profiles of psychological well-being over 9-10 years are predictors of blood lipid profiles. Using the MIDUS (Midlife in the U.S.) biological subsample (n = 1054, aged 34 to 84, 55% female), cross-time trajectories of well-being were linked with three lipid outcomes (i.e., HDL cholesterol, triglycerides, and LDL cholesterol), measured for the first time at the 2nd wave of the study.
resultsMost adults showed largely stable profiles of well-being, albeit at different levels. Some showed persistently high well-being over time, while others revealed persistently low or moderate well-being. After adjusting for the effect of demographics, health behaviors, medications, and insulin resistance, adults with persistently high levels of environmental mastery and self-acceptance-two components of psychological well-being-had significantly higher levels of HDL as well as significantly lower levels of triglycerides compared to adults with persistently low levels of well-being. Converging with prior findings, no association was found between well-being and LDL cholesterol.
conclusionsOver 9-10 years, persistently high levels of psychological well-being measures predicted high HDL cholesterol and low triglycerides. These findings add longitudinal evidence to the growing body of research showing that positive psychological factors are linked with better lipoprotein profiles. A better blood lipid profile, particularly higher HDL-C, may be key in mediating how psychological well-being positively impacts health and length of life. Additional research is required to further validate this hypothesis as well as to establish potential underlying mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.