Evidence map›Paper›PMID 29298693›Full record

ArticleBMC women's health2018

Rubella natural immunity among adolescent girls in Tanzania: the need to vaccinate child bearing aged women.

Mariam M Mirambo, Mtebe Majigo, Seth D Scana, Martha F Mushi, Said Aboud, Uwe Groß, Benson R Kidenya, Stephen E Mshana

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC women's health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mariam M MiramboDepartment of Microbiology and Immunology, Weill Bugando School of medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania. mmmirambo@gmail.com.ORCID 0000-0003-2313-3079
Mtebe MajigoDepartment of Microbiology and Immunology, Muhimbili university of Health and allied sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Seth D ScanaDepartment of Microbiology and Immunology, Weill Bugando School of medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.
Martha F MushiDepartment of Microbiology and Immunology, Weill Bugando School of medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.
Said AboudDepartment of Microbiology and Immunology, Muhimbili university of Health and allied sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Uwe GroßInstitute of Medical Microbiology, University Medical Centre Göttingen, Kreuzbergring 57, 37075, Göttingen, Germany.
Benson R KidenyaDepartment of Epidemiology and Biostatics, School of Public Health, Catholic University of Health and Allied sciences, P.O.Box 1464, Mwanza, Tanzania.
Stephen E MshanaInstitute of Medical Microbiology, University Medical Centre Göttingen, Kreuzbergring 57, 37075, Göttingen, Germany.
Catholic University of Health and Allied Sciences · TZMuhimbili University of Health and Allied Sciences · TZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRubella primary infection during early stages of pregnancy is associated with high risk of congenital Rubella syndrome (CRS). Prevention of CRS in the resource-limited countries requires multiple strategies. Here, we document the data on the magnitude of Rubella natural immunity among adolescent girls which is a crucial group in devising effective control strategies to prevent CRS.

methodsA cross sectional study involving 397 adolescent girls was conducted in the city of Mwanza involving five secondary schools. Socio-demographic and other relevant information were collected using pre-tested data collection tool. Rubella IgG antibodies were determined using enzyme immunoassay. The presence of Rubella IgG titers of >10 IU/ml indicated natural immunity.

resultsThe mean age of the study participants was 15.18 ± 1.48 years. Of 397 girls, 340 (85.6%) and 57 (14.4%) were from secondary schools representing peri-urban and rural areas, respectively. Out of 397 girls, 90.4% (95% CI: 87-93) were found to be naturally immune with median Rubella IgG antibodies titers of 56.7 IU/ml interquartile range (IQR): 40.8-137. The median Rubella IgG antibodies titers were significantly high in adolescent girls from families with high socio-economic status (63.96 vs. 47.13 IU/ml, P < 0.001) and in adolescent girls from peri-urban areas of the city (63.33 vs. 39.9 IU/ml, P < 0.001).

conclusionThe majority of adolescent girls in the city of Mwanza are naturally immune to Rubella virus. There is a need to compare the effectiveness of screening and vaccinating susceptible adolescent girls with the effectiveness of vaccinating all women of childbearing in controlling CRS in low-income countries.

Indexed as

Immunity, InnateVaccinationAdolescentAntibodies, ViralCross-Sectional StudiesFemaleHumansImmunoglobulin GNeeds AssessmentRubellaRubella Syndrome, CongenitalRural PopulationSocial ClassSuburban PopulationTanzaniaAntibodies, ViralImmunoglobulin Grubella antibodiesAdolescent girlsNatural immunityRubellaTanzania

Identifiers

PMID29298693
PMCPMC5751833
OpenAlexW2782531852

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.