ArticleCurrent Alzheimer research2018
An Inflammation-related Nutrient Pattern is Associated with Both Brain and Cognitive Measures in a Multiethnic Elderly Population.
Article in Current Alzheimer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex consideration in diet-biomarker-related indices: a systematic review.Public health nutrition · 2018Pooled it
- The association between a pro-inflammatory diet and brain age in middle-aged and older adults.European journal of epidemiology · 2026Article
- Longitudinal Association of Inflammatory Diets on Cognition in Older Adults: Insights from the Oral-Gut-Brain Axis.Journal of the American Geriatrics Society · 2025Article
- Dietary inflammatory index and brain disorders: a Large Prospective Cohort study.Translational psychiatry · 2025Article
- The Impact of the Exposome on Alzheimer's Disease: The Influence of Nutrition.International journal of molecular sciences · 2025Review
- Uncovering the relationship between trace element exposure, cognitive function, and dietary inflammation index in elderly americans from the National Health and Nutrition Examination Survey 2011-2014.BMC public health · 2024Article
- Chronic Low-Grade Inflammation and Brain Structure in the Middle-Aged and Elderly Adults.Nutrients · 2024Article
- Effect of Mediterranean Dietary Pattern on Cognitive Status in Community-Dwelling Older Adults.Nutrients · 2023Article
- Diet, pace of biological aging, and risk of dementia in the Framingham Heart Study.medRxiv : the preprint server for health sciences · 2023Article
- Plasma proteins related to inflammatory diet predict future cognitive impairment.Molecular psychiatry · 2023Article
- An Oxylipin-Related Nutrient Pattern and Risk of Type 1 Diabetes in the Diabetes Autoimmunity Study in the Young (DAISY).Nutrients · 2023Article
- Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study.Alzheimer's research & therapy · 2023Article
- The relationship between dietary patterns derived from inflammation and cognitive impairment in patients undergoing hemodialysis.Frontiers in nutrition · 2023Article
- Larger dlPFC and vmPFC grey matter volumes are associated with high adherence to the Mediterranean diet: A cross-sectional study in older adults.Aging brain · 2023Article
- Empirical Dietary Inflammatory Pattern Scores Are Not Associated with Worse Cognitive Performance in the Nurses' Health Study.The Journal of nutrition · 2022Article
- Mediterranean Diet and White Matter Hyperintensity Change over Time in Cognitively Intact Adults.Nutrients · 2022Article
- Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group.The lancet. Healthy longevity · 2022Article
- Review
- Comparison of the Impact of the Mediterranean Diet, Anti-Inflammatory Diet, Seventh-Day Adventist Diet, and Ketogenic Diet Relative to Cognition and Cognitive Decline.Current nutrition reports · 2022Review
- Nutrient patterns and depressive symptoms among Australian adults.European journal of nutrition · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundAccumulating evidence suggests that dietary factors are associated with Alzheimer's disease, cognition, and brain health in older adults. It is however unclear whether inflammation explains this association.
objectiveTo examine whether an inflammation-related nutrient pattern (INP) was associated with neuroimaging and cognitive measures of brain health.
methodThe current cross-sectional study included 330 non-demented elderly (mean age 79 years at MRI scan) participants in a multi-ethnic, community-based cohort study who had information on nutritional intake (estimated from food frequency questionnaire), circulating C-reactive protein and interleukin- 6 (measured by ELISA), MRI scans, and cognition. Diet and blood samples were collected approximately 5.3 years prior to the MRI and cognitive test visit. We used a reduced rank regression model to derive an INP based on 24 nutrients' relationship with CRP and interleukin-6. We examined the association of the INP with brain and cognitive measures using regression models adjusted for age, sex, race/ethnicity, education, caloric intake, APOE genotype, body mass index, and vascular burden, as well as intracranial volume for the brain MRI measures.
resultsThe INP was characterized by low intake (effect loading <-0.15) of calcium, vitamins (D, E, A, B1, B2, B3, B5, B6), folate, Ω-3 poly-unsaturated fatty acids, and high intake (>0.15) of cholesterol. As designed, this INP was positively correlated with CRP (Pearson's r=0.25 p=0.005) and interleukin-6 (r=0.30, p<0.0001). Each unit increase in INP was associated with 36.8 cm3 (p=0.023) smaller total brain volume and 0.21 (p=0.038) lower visuospatial z-score. Mediation analysis showed that TGMV (b=0.002, p=0.003) was associated with visuospatial cognitive function, and there was a significant mediation effect by TGMV (indirect effect: -0.049, 95% CI: -0.1121 ~ -0.0131) for the association between INP and visuospatial cognitive score.
conclusionsAmong older adults, a diet with high inflammatory potential is associated with less favorable brain and cognitive health.
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