ArticleCell reports2018
Anterior Cingulate Cortex Input to the Claustrum Is Required for Top-Down Action Control.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.
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Who cites it
103 citing papers in PubMed, 1 synthesis or guideline pooled it, 196 citations in OpenAlex.
- Brain responses to social punishment: a meta-analysis.Scientific reports · 2019Pooled it
- Human claustrum neurons encode uncertainty and prediction errors during aversive learning.Nature neuroscience · 2026Article
- A claustro-cortical loop times state transitions for flexible behavior.Research square · 2026Article
- Anterior cingulate cortex activation of claustrum projection neuron subtypes is enhanced by alcohol.Neuropharmacology · 2026Article
- New functional insights from the monkey claustrum.National science review · 2026Review
- A claustro-cortical loop times state transitions for flexible behavior.bioRxiv : the preprint server for biology · 2026Article
- Parallel anterior cingulate cortex pathways underlie dissociable social and attentional outputs.Science advances · 2026Article
- The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchy.PLoS biology · 2026Article
- The Human Visual Claustrum Responses to Physical Stimulus Properties and Subjective Content During Movie Viewing.Human brain mapping · 2026Article
- The human claustrum supports cognitive networks for externally and internally driven task demands.PLoS biology · 2026Article
- Article
- Cell-type-specific sustained value representations in the claustrum.bioRxiv : the preprint server for biology · 2026Article
- Nurr1 Orchestrates Claustrum Development and Functionality.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The interconnected wirings between medial prefrontal cortex and claustrum and their governing roles in the methamphetamine reward memory in male mice.Nature communications · 2026Article
- The Human Claustrum Activates Across Multiple Cognitive Control Tasks.The European journal of neuroscience · 2025Article
- Psychedelics Reverse the Polarity of Long-Term Synaptic Plasticity in Cortical-Projecting Claustrum Neurons.eNeuro · 2025Article
- A spatial single-cell atlas of the claustro-insular region uncovers key regulators of neuronal identity and excitability.Nature communications · 2025Article
- Serotonin and psilocybin activate 5-HTNature communications · 2025Article
- A Contrast-Agnostic Method for Ultra-High Resolution Claustrum Segmentation.Human brain mapping · 2025Article
- A comprehensive and reliable protocol for manual segmentation of the human claustrum using high-resolution MRI.Brain structure & function · 2025Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Cognitive abilities, such as volitional attention, operate under top-down, executive frontal cortical control of hierarchically lower structures. The circuit mechanisms underlying this process are unresolved. The claustrum possesses interconnectivity with many cortical areas and, thus, is hypothesized to orchestrate the cortical mantle for top-down control. Whether the claustrum receives top-down input and how this input may be processed by the claustrum have yet to be formally tested, however. We reveal that a rich anterior cingulate cortex (ACC) input to the claustrum encodes a preparatory top-down information signal on a five-choice response assay that is necessary for optimal task performance. We further show that ACC input monosynaptically targets claustrum inhibitory interneurons and spiny glutamatergic projection neurons, the latter of which amplify ACC input in a manner that is powerfully constrained by claustrum inhibitory microcircuitry. These results demonstrate ACC input to the claustrum is critical for top-down control guiding action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.