Evidence map›Paper›PMID 29298434›Full record

ArticleCell reports2018

Coiled-Coil Formation Conveys a STIM1 Signal from ER Lumen to Cytoplasm.

Nupura Hirve, Vangipurapu Rajanikanth, Patrick G Hogan, Aparna Gudlur

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 81 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Listening to the quiescence of single STIM1 dimers.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Multiple weak brakes act in concert to control STIM1 and store-operated calcium entry.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. STIM1 transmembrane helix dimerization captured by AI-guided transition path sampling.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Review
  10. Article
  11. The Molecular Biology of Placental Transport of Calcium to the Human Foetus.International journal of molecular sciences · 2025
    Review
  12. Article
  13. Article
  14. Essential role of N-terminal SAM regions in STIM1 multimerization and function.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nupura HirveDivision of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
Vangipurapu RajanikanthDivision of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
Patrick G HoganDivision of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA; Program in Immunology, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: phogan@lji.org.
Aparna GudlurDivision of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.
La Jolla Institute for Immunology · USUniversity of California, San Diego · US

Funding

SIGNAL TRANSDUCTION AND GENE INDUCTION IN T LYMPHOCYTESR01AI040127 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK, RAO, ANJANA · 1996 to 2025
$13.3M
NFAT, bZIP proteins, and transcriptional programs in lymphocytesR01AI109842 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Patrick Hogan, Anjana Rao · 2014 to 2026
$8.6M
STIM-ORAI signaling and other calcium influx pathways in lymphocytesR01AI084167 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK · 2009 to 2019
$4.9M
NIAID NIH HHS R01 AI040127NIAID NIH HHS R01 AI084167NIAID NIH HHS R01 AI109842
6 · The paper itself

Abstract

STIM1 and STIM2 are endoplasmic reticulum (ER) membrane proteins that sense decreases in ER-luminal free Ca

Indexed as

Ion Channel GatingSignal TransductionCytoplasmEndoplasmic ReticulumHeLa CellsHumansIntracellular MembranesNeoplasm ProteinsORAI1 ProteinProtein DomainsProtein MultimerizationProtein Structure, SecondaryStromal Interaction Molecule 1Neoplasm ProteinsORAI1 ProteinORAI1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1calcium imagingcoiled coilconformational changedisulfide crosslinkingER-plasma membrane junctionevolutionSTIM1STIM2store-operated calcium entrytransmembrane

Identifiers

PMID29298434
PMCPMC5755632
OpenAlexW2781901033

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.