Evidence map›Paper›PMID 29298419›Full record

ArticleCell reports2018

Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B.

J J David Ho, Nathan C Balukoff, Grissel Cervantes, Petrice D Malcolm, Jonathan R Krieger, Stephen Lee

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
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    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

J J David HoDepartment of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Nathan C BalukoffDepartment of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Grissel CervantesDepartment of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Petrice D MalcolmDepartment of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Jonathan R KriegerThe SickKids Proteomics, Analytics, Robotics & Chemical Biology Centre (SPARC BioCentre), The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
Stephen LeeDepartment of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Urology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Electronic address: stephenlee@med.miami.edu.
University of Miami · USSylvester Comprehensive Cancer Center · USSickKids Foundation · CA

Funding

The Nucleolar Detention Center: a Hub of Long Noncoding RNAs that Imprison Proteins During StressR01GM115342 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LEE, STEPHEN · 2015 to 2022
$2.6M
Induction of Tumor Cell Dormancy by Ribosomal Intergenic Spacer Noncoding RNAR01CA200676 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LEE, STEPHEN · 2016 to 2020
$1.7M
CIHRNCI NIH HHS R01 CA200676NIGMS NIH HHS R01 GM115342
6 · The paper itself

Abstract

The eukaryotic translation initiation factor 5B (eIF5B) is a homolog of IF2, an ancient translation factor that enables initiator methionine-tRNAi

Indexed as

Protein BiosynthesisA549 CellsActivating Transcription Factor 4AerobiosisCarbonCell HypoxiaEukaryotic Initiation Factor-2Eukaryotic Initiation FactorsHumansMCF-7 CellsOxygenActivating Transcription Factor 4ATF4 protein, humanCarbonEukaryotic Initiation Factor-2eukaryotic initiation factor-5BEukaryotic Initiation FactorsOxygenATF4carbon metabolismeIF5BevolutionglycolysishypoxiaIF2MATRIXstresstranslation

Identifiers

PMID29298419
PMCPMC5786279
OpenAlexW2781690565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.