Evidence map›Paper›PMID 29298341›Full record

ArticlePloS one2018

3D reconstruction of coronary arteries from 2D angiographic projections using non-uniform rational basis splines (NURBS) for accurate modelling of coronary stenoses.

Francesca Galassi, Mohammad Alkhalil, Regent Lee, Philip Martindale, Rajesh K Kharbanda, Keith M Channon, Vicente Grau, Robin P Choudhury

Open access · goldAbstract readValidation Study
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 47 citations in OpenAlex.

  1. Spatiotemporally constrained 3D reconstruction from biplanar digital subtraction angiography.International journal of computer assisted radiology and surgery · 2025
    Article
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  3. Dynamic multispectral NIR/SWIR forJournal of biomedical optics · 2024
    Article
  4. Patient-specificFrontiers in cardiovascular medicine · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Using temporal and structural data to reconstruct 3D cerebral vasculature from a pair of 2D digital subtraction angiography sequences.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Francesca GalassiRadcliffe Department of Medicine, Oxford Acute Vascular Imaging Centre, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-4298-4170
Mohammad AlkhalilRadcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom.
Regent LeeNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Philip MartindaleOxford Heart Centre, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Rajesh K KharbandaRadcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom.
Keith M ChannonRadcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom.
Vicente GrauDepartment of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom.
Robin P ChoudhuryRadcliffe Department of Medicine, Oxford Acute Vascular Imaging Centre, University of Oxford, Oxford, United Kingdom.
University of Oxford · GB

Funding

British Heart Foundation NH/13/1/30238British Heart Foundation PG/15/110/31936
6 · The paper itself

Abstract

objectiveAssessment of coronary stenosis severity is crucial in clinical practice. This study proposes a novel method to generate 3D models of stenotic coronary arteries, directly from 2D coronary images, and suitable for immediate assessment of the stenosis severity.

methodsFrom multiple 2D X-ray coronary arteriogram projections, 2D vessels were extracted. A 3D centreline was reconstructed as intersection of surfaces from corresponding branches. Next, 3D luminal contours were generated in a two-step process: first, a Non-Uniform Rational B-Spline (NURBS) circular contour was designed and, second, its control points were adjusted to interpolate computed 3D boundary points. Finally, a 3D surface was generated as an interpolation across the control points of the contours and used in the analysis of the severity of a lesion. To evaluate the method, we compared 3D reconstructed lesions with Optical Coherence Tomography (OCT), an invasive imaging modality that enables high-resolution endoluminal visualization of lesion anatomy.

resultsValidation was performed on routine clinical data. Analysis of paired cross-sectional area discrepancies indicated that the proposed method more closely represented OCT contours than conventional approaches in luminal surface reconstruction, with overall root-mean-square errors ranging from 0.213mm2 to 1.013mm2, and maximum error of 1.837mm2. Comparison of volume reduction due to a lesion with corresponding FFR measurement suggests that the method may help in estimating the physiological significance of a lesion.

conclusionThe algorithm accurately reconstructed 3D models of lesioned arteries and enabled quantitative assessment of stenoses. The proposed method has the potential to allow immediate analysis of the stenoses in clinical practice, thereby providing incremental diagnostic and prognostic information to guide treatments in real time and without the need for invasive techniques.

Indexed as

Models, BiologicalAlgorithmsCoronary AngiographyCoronary StenosisCoronary VesselsHumansImaging, Three-Dimensional

Identifiers

PMID29298341
PMCPMC5752011
OpenAlexW2782131774

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.