ArticlePsychosomatic medicine2018
Heart Rate Variability and Its Relation to Chronic Kidney Disease: Results From the PREVEND Study.
Article in Psychosomatic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- A Health Literacy Intervention Targeting Chronic Kidney Disease Patients and Healthcare Professionals is Cost-saving: Findings from the Netherlands.Journal of general internal medicine · 2026Article
- Heart Rate Variability Applications in Medical Specialties: A Narrative Review.Applied psychophysiology and biofeedback · 2025Review
- A composite measurement concept for monitoring cardiac function in Fabry disease.Orphanet journal of rare diseases · 2025Article
- Association between heart rate fragmentation and kidney function decline in MESA: evidence consistent with parasympathetic degradation.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Heart rate transition patterns reveal autonomic dysfunction in heart failure with renal function decline: a symbolic and Markov model approach.BioData mining · 2025Article
- The heart rate non-dipping pattern was associated with target organ damage in patients with chronic kidney disease.International urology and nephrology · 2024Article
- Autonomic activity and cardiovascular system risk assessment in pediatric patients with hemolytic uremic syndrome.European journal of pediatrics · 2024Article
- The Role of Heart Rate Variability (HRV) in Different Hypertensive Syndromes.Diagnostics (Basel, Switzerland) · 2023Review
- Effects of a Combined Intradialytic Exercise Training Program and Music on Cardiac Autonomic Nervous System Activity in Hemodialysis Patients.Life (Basel, Switzerland) · 2022Article
- Factors Associated with Reduced Heart Rate Variability in the General Japanese Population: The Iwaki Cross-Sectional Research Study.Healthcare (Basel, Switzerland) · 2022Article
- Polyunsaturated Fatty Acid EAB-277Frontiers in veterinary science · 2022Article
- Cardiac Autonomic Dysfunction Is Associated With Risk of Diabetic Kidney Disease Progression in Type 2 Diabetes Mellitus.Frontiers in endocrinology · 2022Article
- Role of Heart Rate Variability in Association Between Glomerular Hyperfiltration and All-Cause Mortality.Journal of the American Heart Association · 2021Article
- Article
- Nocturnal pulse rate correlated with ambulatory blood pressure and target organ damage in patients with chronic kidney disease.Journal of clinical hypertension (Greenwich, Conn.) · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn the general population, reduced heart rate variability (HRV) has been associated with cardiovascular disease. However, its relation to chronic kidney disease (CKD) is debated. We therefore investigated the relation between low HRV and renal outcomes.
methodsIn the population-based Prevention of REnal and Vascular ENdstage Disease study, renal outcomes (CKD, estimated glomerular filtration rate [eGFR], urinary albumin) were measured at baseline and three consecutive examinations. HRV measures (among which SDNN [standard deviation of normal-to-normal RR intervals]) were calculated from time series of beat-to-beat pulse wave recordings at baseline. The lowest (risk) quartile was compared with the upper three quartiles combined, in multivariable survival and linear mixed-effects analyses.
resultsIn 4605 participants (49% males, age range = 33-80, 0.6% blacks), we observed 341 new participants of CKD during a median follow-up duration of 7.4 years. Low SDNN was associated with higher incidence of CKD (crude HR = 1.66, 95% CI = 1.30 to 2.12, p < .001), but this association was no longer significant after adjustment for age, sex, and cardiovascular risk factors (adjusted HR = 1.13, 95% CI = 0.86 to 1.48, p = .40, similar for other HRV measures). No associations between SDNN and eGFR trajectories were found in the total sample. However, in a subgroup of participants with baseline CKD (n = 939), we found a significant association of low SDNN (but not other HRV measures) with lower baseline eGFR, even after multivariable adjustment (adjusted βlevel difference = -3.73 ml/min/1.73 m, 95% CI = -6.70 to -0.75, p = .014), but not with steeper eGFR decline.
conclusionsThese results suggest that reduced HRV may be a complication of CKD rather than a causal factor.
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