Evidence map›Paper›PMID 29298115›Full record

ArticleJournal of oncology practice2018

Caution Ahead: Research Challenges of a Randomized Controlled Trial Implemented to Improve Breast Cancer Treatment at Safety-Net Hospitals.

Nina A Bickell, Ajay Shah, Maria Castaldi, Theophilus Lewis, Alan Sickles, Shalini Arora, Kevin Clarke, Margaret Kemeny, Anitha Srinivasan, Kezhen Fei and 4 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of oncology practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nina A BickellIcahn School of Medicine at Mount Sinai, Metropolitan Hospital Center, New York; Bronx-Lebanon Hospital Center, Jacobi Medical Center, Bronx; Kings County Hospital Center, NYU Lutheran Medical Center, Brooklyn Hospital Center, Brooklyn; Elmhurst Hospital Center, Elmhurst; Queens Cancer Center, Jamaica, NY; Newark Beth Israel Medical Center, Newark, NJ; and The Ohio State University, Columbus, OH.
Ajay ShahIcahn School of Medicine at Mount Sinai, Metropolitan Hospital Center, New York; Bronx-Lebanon Hospital Center, Jacobi Medical Center, Bronx; Kings County Hospital Center, NYU Lutheran Medical Center, Brooklyn Hospital Center, Brooklyn; Elmhurst Hospital Center, Elmhurst; Queens Cancer Center, Jamaica, NY; Newark Beth Israel Medical Center, Newark, NJ; and The Ohio State University, Columbus, OH.
Maria CastaldiIcahn School of Medicine at Mount Sinai, Metropolitan Hospital Center, New York; Bronx-Lebanon Hospital Center, Jacobi Medical Center, Bronx; Kings County Hospital Center, NYU Lutheran Medical Center, Brooklyn Hospital Center, Brooklyn; Elmhurst Hospital Center, Elmhurst; Queens Cancer Center, Jamaica, NY; Newark Beth Israel Medical Center, Newark, NJ; and The Ohio State University, Columbus, OH.
Theophilus LewisIcahn School of Medicine at Mount Sinai, Metropolitan Hospital Center, New York; Bronx-Lebanon Hospital Center, Jacobi Medical Center, Bronx; Kings County Hospital Center, NYU Lutheran Medical Center, Brooklyn Hospital Center, Brooklyn; Elmhurst Hospital Center, Elmhurst; Queens Cancer Center, Jamaica, NY; Newark Beth Israel Medical Center, Newark, NJ; and The Ohio State University, Columbus, OH.
Alan SicklesIcahn School of Medicine at Mount Sinai, Metropolitan Hospital Center, New York; Bronx-Lebanon Hospital Center, Jacobi Medical Center, Bronx; Kings County Hospital Center, NYU Lutheran Medical Center, Brooklyn Hospital Center, Brooklyn; Elmhurst Hospital Center, Elmhurst; Queens Cancer Center, Jamaica, NY; Newark Beth Israel Medical Center, Newark, NJ; and The Ohio State University, Columbus, OH.
Shalini AroraIcahn School of Medicine at Mount Sinai, Metropolitan Hospital Center, New York; Bronx-Lebanon Hospital Center, Jacobi Medical Center, Bronx; Kings County Hospital Center, NYU Lutheran Medical Center, Brooklyn Hospital Center, Brooklyn; Elmhurst Hospital Center, Elmhurst; Queens Cancer Center, Jamaica, NY; Newark Beth Israel Medical Center, Newark, NJ; and The Ohio State University, Columbus, OH.
Kevin ClarkeIcahn School of Medicine at Mount Sinai, Metropolitan Hospital Center, New York; Bronx-Lebanon Hospital Center, Jacobi Medical Center, Bronx; Kings County Hospital Center, NYU Lutheran Medical Center, Brooklyn Hospital Center, Brooklyn; Elmhurst Hospital Center, Elmhurst; Queens Cancer Center, Jamaica, NY; Newark Beth Israel Medical Center, Newark, NJ; and The Ohio State University, Columbus, OH.
Margaret KemenyIcahn School of Medicine at Mount Sinai, Metropolitan Hospital Center, New York; Bronx-Lebanon Hospital Center, Jacobi Medical Center, Bronx; Kings County Hospital Center, NYU Lutheran Medical Center, Brooklyn Hospital Center, Brooklyn; Elmhurst Hospital Center, Elmhurst; Queens Cancer Center, Jamaica, NY; Newark Beth Israel Medical Center, Newark, NJ; and The Ohio State University, Columbus, OH.
Anitha SrinivasanIcahn School of Medicine at Mount Sinai, Metropolitan Hospital Center, New York; Bronx-Lebanon Hospital Center, Jacobi Medical Center, Bronx; Kings County Hospital Center, NYU Lutheran Medical Center, Brooklyn Hospital Center, Brooklyn; Elmhurst Hospital Center, Elmhurst; Queens Cancer Center, Jamaica, NY; Newark Beth Israel Medical Center, Newark, NJ; and The Ohio State University, Columbus, OH.
Kezhen FeiIcahn School of Medicine at Mount Sinai, Metropolitan Hospital Center, New York; Bronx-Lebanon Hospital Center, Jacobi Medical Center, Bronx; Kings County Hospital Center, NYU Lutheran Medical Center, Brooklyn Hospital Center, Brooklyn; Elmhurst Hospital Center, Elmhurst; Queens Cancer Center, Jamaica, NY; Newark Beth Israel Medical Center, Newark, NJ; and The Ohio State University, Columbus, OH.
Rebeca FrancoIcahn School of Medicine at Mount Sinai, Metropolitan Hospital Center, New York; Bronx-Lebanon Hospital Center, Jacobi Medical Center, Bronx; Kings County Hospital Center, NYU Lutheran Medical Center, Brooklyn Hospital Center, Brooklyn; Elmhurst Hospital Center, Elmhurst; Queens Cancer Center, Jamaica, NY; Newark Beth Israel Medical Center, Newark, NJ; and The Ohio State University, Columbus, OH.
Michael ParidesIcahn School of Medicine at Mount Sinai, Metropolitan Hospital Center, New York; Bronx-Lebanon Hospital Center, Jacobi Medical Center, Bronx; Kings County Hospital Center, NYU Lutheran Medical Center, Brooklyn Hospital Center, Brooklyn; Elmhurst Hospital Center, Elmhurst; Queens Cancer Center, Jamaica, NY; Newark Beth Israel Medical Center, Newark, NJ; and The Ohio State University, Columbus, OH.
Peter PappasIcahn School of Medicine at Mount Sinai, Metropolitan Hospital Center, New York; Bronx-Lebanon Hospital Center, Jacobi Medical Center, Bronx; Kings County Hospital Center, NYU Lutheran Medical Center, Brooklyn Hospital Center, Brooklyn; Elmhurst Hospital Center, Elmhurst; Queens Cancer Center, Jamaica, NY; Newark Beth Israel Medical Center, Newark, NJ; and The Ohio State University, Columbus, OH.
Ann Scheck McAlearneyIcahn School of Medicine at Mount Sinai, Metropolitan Hospital Center, New York; Bronx-Lebanon Hospital Center, Jacobi Medical Center, Bronx; Kings County Hospital Center, NYU Lutheran Medical Center, Brooklyn Hospital Center, Brooklyn; Elmhurst Hospital Center, Elmhurst; Queens Cancer Center, Jamaica, NY; Newark Beth Israel Medical Center, Newark, NJ; and The Ohio State University, Columbus, OH.

Funding

Implementing a Tracking & Feedback Registry to Allay Cancer Therapy DisparitiesR01CA149025 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BICKELL, NINA A. · 2010 to 2014
$2.9M
NCI NIH HHS R01 CA149025
6 · The paper itself

Abstract

purposeTo implement and test a Web-based tracking and feedback (T&F) tool to close referral loops and reduce adjuvant breast cancer treatment underuse in safety-net hospitals (SNHs). PATIENT AND

methodsWe randomly assigned 10 SNHs, identified patients with new stage 1 to stage 3 breast cancer, assessed their connection with the oncologist, and relayed this information to surgeons for follow-up. We interviewed key informants about the tool's usefulness. We conducted intention-to-treat and pre- and poststudy analyses to assess the T&F tool and implementation effectiveness, respectively.

resultsBetween the study start and intervention implementation, several hospitals reorganized care delivery and 49% of patients scheduled to undergo breast cancer surgery were ineligible because they already were in contact with an oncologist. One high-volume hospital closed. Despite randomization of hospitals, intervention (INT) hospitals had fewer white patients (5% v 16%; P = .0005), and more underuse (28% v 15%; P = .002) compared with usual care (UC) hospitals. Over time, INT hospitals with poorer follow-up significantly reduced underuse compared with UC hospitals (INT hospitals, from 33% to 9%, P = .001 v UC hospitals, from 15% to 11%, P = .5). There was no difference in underuse (9% at INT hospitals, 11% at UC hospitals; P = .8). Hospitals with better follow-up (odds ratio, 0.85; 95% CI, 0.73 to 0.98) had less underuse. In settings with poor follow-up and tracking approaches, key informants found the tool useful. The rapidly changing delivery landscape posed significant challenges to this implementation research.

conclusionA T&F tool did not significantly reduce adjuvant underuse but may help reduce underuse in SNHs with poor follow-up capabilities. Inability to discern T&F effectiveness is likely due to encountered challenges that inform lessons for future implementation research.

Indexed as

HospitalsQuality ImprovementRandomized Controlled Trials as TopicSafety-net ProvidersBreast NeoplasmsFemaleHumansIntention to Treat AnalysisMedical Informatics ApplicationsNew York CityTreatment Outcome

Identifiers

PMID29298115
PMCPMC6550054

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.