Evidence map›Paper›PMID 29298104›Full record

ArticleJournal of palliative medicine2018

Associations between Mild Cognitive Dysfunction and End-of-Life Outcomes in Patients with Advanced Cancer.

Keiko Kurita, M Cary Reid, Eugenia L Siegler, Eli L Diamond, Holly G Prigerson

Abstract readMulticenter Study
In one paragraph

Article in Journal of palliative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Ethics consultations in neuro-oncology.Neuro-oncology practice · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Keiko Kurita1 Center for Research on End-of-Life Care , Weill Cornell Medicine, New York, New York.
M Cary Reid2 Division of Geriatrics and Palliative Medicine, Department of Medicine, Weill Cornell Medicine , New York, New York.
Eugenia L Siegler2 Division of Geriatrics and Palliative Medicine, Department of Medicine, Weill Cornell Medicine , New York, New York.
Eli L Diamond3 Department of Neurology, Memorial Sloan Kettering Cancer Center , New York, New York.
Holly G Prigerson1 Center for Research on End-of-Life Care , Weill Cornell Medicine, New York, New York.
Weill Cornell Medicine · USCornell University · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
Psychosocial Approaches to Better Understanding & End-Stage Cancer Care (PROTECT)R35CA197730 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Holly Gwen Prigerson · 2015 to 2026
$11.2M
The Weill Cornell Medicine Research Training Program in Behavioral GeriatricsT32AG049666 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI SARA J CZAJA, Manney Carrington Reid · 2016 to 2026
$3.2M
Reid Aging and Pain Research Training ProgramK24AG053462 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI REID, MANNEY CARRINGTON · 2016 to 2025
$1.8M
NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA197730NIA NIH HHS K24 AG053462NIA NIH HHS T32 AG049666
6 · The paper itself

Abstract

backgroundCognitive function of patients with advanced cancer is frequently compromised.

objectiveTo determine the extent that patients' cognitive screening scores was associated with their end-of-life (EoL) treatment preferences, advance care planning (ACP), and care.

designPatients were interviewed at baseline and administered a cognitive screen. Caregivers completed a postmortem assessment. SETTING/SUBJECTS: Patients with distant metastases and disease progression after first-line chemotherapy and their caregivers (n = 609) were recruited from outpatient clinics and completed baseline and postmortem assessments. MEASUREMENTS: In logistic regression models adjusting for patients' age, education level, and performance status, patients' scores on the Pfeiffer Short Portable Mental Status exam at baseline predicted ACP, treatments, and treatment preferences at baseline, and location of death and caregiver perceptions of the patients' death in a postmortem assessment.

resultsFor each additional error, patients were less likely to consider the intensive care unit a bad place to die (adjusted odds ratio [AOR] = 0.81; confidence interval [95% CI]: 0.66-0.98; p = 0.03) and less likely to have an inpatient hospice stay (AOR = 0.63; 95% CI: 0.40-1.00; p = 0.05). After death (n = 318), caregivers were more likely to perceive that patients died at patients' preferred location (AOR = 1.38; 95% CI: 1.01-1.88; p = 0.04) and less likely to perceive that patients preferred to extend life over relieving discomfort (AOR = 0.63; 95% CI: 0.40-0.99; p = 0.05).

conclusionsPatient cognitive screening scores were associated with EoL outcomes. Rather than avoid patients who are cognitively impaired, oncologists should consider ACP with them.

Indexed as

Palliative CareAdvance Care PlanningCognitive DysfunctionDecision MakingFemaleHumansInterviews as TopicLongitudinal StudiesMaleMiddle AgedNeoplasmsPatient PreferenceProspective StudiesTerminally Illcognitive dysfunctionend-of-life outcomespatients with advanced cancer

Identifiers

PMID29298104
PMCPMC5867505
OpenAlexW2781889477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.