Evidence map›Paper›PMID 29297928›Full record

ArticleImmunology2018

P21-activated kinase 2 is essential in maintenance of peripheral Foxp3

Jinyong Choi, David Randall Pease, Siqi Chen, Bin Zhang, Hyewon Phee

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. TcdB ofInternational journal of molecular sciences · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jinyong ChoiDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-2474-2837
David Randall PeaseDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Siqi ChenDepartment of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Bin ZhangDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Hyewon PheeDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-1942-0414
Northwestern University · US

Funding

The GIT2-PIX-PAK complex in T cell migration, activation and arthritisK01AR059754 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PHEE, HYEWON · 2010 to 2014
$598k
NIAMS NIH HHS K01 AR059754
6 · The paper itself

Abstract

The p21-activated kinase 2 (Pak2), an effector molecule of the Rho family GTPases Rac and Cdc42, regulates diverse functions of T cells. Previously, we showed that Pak2 is required for development and maturation of T cells in the thymus, including thymus-derived regulatory T (Treg) cells. However, whether Pak2 is required for the functions of various subsets of peripheral T cells, such as naive CD4 and helper T-cell subsets including Foxp3

Indexed as

AnimalsBiomarkersCD4-Positive T-LymphocytesCell DifferentiationForkhead Transcription FactorsGene Knockdown TechniquesHomeostasisInterleukin-17Lymphocyte ActivationMiceMice, Transgenicp21-Activated KinasesPhosphorylationReceptors, Antigen, T-CellTh17 CellsT-Lymphocytes, RegulatoryBiomarkersForkhead Transcription FactorsFoxp3 protein, mouseIl17a protein, mouseInterleukin-17p21-Activated KinasesPak2 protein, mouseReceptors, Antigen, T-CellCD4 cellregulatory T cellsT-cell receptors

Identifiers

PMID29297928
PMCPMC5980155
OpenAlexW2782204654

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.