ArticleLaboratory investigation; a journal of technical methods and pathology2018
Cholecystectomy: a way forward and back to metabolic syndrome?
Article in Laboratory investigation; a journal of technical methods and pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05557669 (Effect of Laparoscopic Cholecystectomy on Risk of Metabolic Syndrome), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Laparoscopic Cholecystectomy on Risk of Metabolic Syndrome
Who cites it
19 citing papers in PubMed.
- Cholecystectomy Is Linked With Lower Respiratory Exchange Ratio and Higher Lipid Oxidation and Sleep Energy Expenditure.Obesity (Silver Spring, Md.) · 2026Observational
- Weekend warrior physical activity patterns can reduce the risk of gallstone formation: NHANES 2017-2020 and Mendelian randomization analyses.Archives of medical science : AMS · 2026Article
- Association between cholecystectomy and the risk of new-onset metabolic dysfunction-associated steatotic liver disease: a risk-stratified cohort study.Scientific reports · 2025Article
- Mortality and cardiovascular disease after cholecystectomy in type 2 diabetes: A nationwide longitudinal cohort study.Journal of hepato-biliary-pancreatic sciences · 2025Article
- Hepatic steatosis mediates the relationship between cholecystectomy and BMI increase: a population-based study.Frontiers in medicine · 2025Article
- Cholecystectomy Increases the Risk of Chronic Kidney Disease: A Nationwide Longitudinal Cohort Study.Journal of clinical medicine · 2024Article
- Association between visceral lipid accumulation indicators and gallstones: a cross-sectional study based on NHANES 2017-2020.Lipids in health and disease · 2024Article
- A Machine Learning-Based Method for Detecting Liver Fibrosis.Diagnostics (Basel, Switzerland) · 2023Article
- Cholecystectomy increases the risk of metabolic syndrome in the Korean population: a longitudinal cohort study.Hepatobiliary surgery and nutrition · 2023Article
- Effects of Bile Acid Modulation by Dietary Fat, Cholecystectomy, and Bile Acid Sequestrant on Energy, Glucose, and Lipid Metabolism and Gut Microbiota in Mice.International journal of molecular sciences · 2022Article
- Cholecystectomy Concomitant with Bariatric Surgery: Safety and Metabolic Effects.Obesity surgery · 2022Article
- Intestinal Barrier and Permeability in Health, Obesity and NAFLD.Biomedicines · 2021Review
- Bile Acids and GPBAR-1: Dynamic Interaction Involving Genes, Environment and Gut Microbiome.Nutrients · 2020Review
- Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF).Genes · 2020Review
- Liver Steatosis, Gut-Liver Axis, Microbiome and Environmental Factors. A Never-Ending Bidirectional Cross-Talk.Journal of clinical medicine · 2020Review
- Physical Activity Modulating Lipid Metabolism in Gallbladder Diseases.Journal of gastrointestinal and liver diseases : JGLD · 2020Review
- Gastrointestinal defects in gallstone and cholecystectomized patients.European journal of clinical investigation · 2019Article
- Cholecystectomy and risk of metabolic syndrome.European journal of internal medicine · 2018Review
- Comparison of fibroblast growth factor 19 concentrations between dogs with and without gallbladder mucoceles.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The gallbladder provides rhythmic secretion of concentrated bile acids (BAs) during fasting and postprandially contributes to digestion of dietary lipids. In addition, BAs activate metabolic pathways governing gluco-lipid homeostasis and energy expenditure via the farnesoid X nuclear receptor (FXR), G protein-coupled BA receptor 1 (GPBAR-1), and fibroblast growth factor 19 (FGF19) in the liver, intestine, brown fat, and muscle. Cholecystectomy is standard treatment worldwide for symptomatic gallstone patients. As excellently reviewed by Chen et al, cholecystectomy may disrupt enterohepatic recycling of, and signaling by, BAs. Further studies are needed to investigate whether gallbladder removal is an independent risk factor for development of the metabolic syndrome.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.