ArticleJournal of biomedical optics2018
Method for accurate registration of tissue autofluorescence imaging data with corresponding histology: a means for enhanced tumor margin assessment.
Article in Journal of biomedical optics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Registration-based 3D Light Sheet Fluorescence Microscopy and 2D histology image fusion tool for pathological specimen.Scientific reports · 2026Article
- Method for co-registration of high-resolution specimen PET-CT with histopathology to improve insight into radiotracer distributions.EJNMMI physics · 2024Article
- Deformable multi-modal image registration for the correlation between optical measurements and histology images.Journal of biomedical optics · 2024Article
- Applications of machine learning in time-domain fluorescence lifetime imaging: a review.Methods and applications in fluorescence · 2024Review
- Point Projection Mapping System for Tracking, Registering, Labeling, and Validating Optical Tissue Measurements.Journal of imaging · 2024Article
- Generative adversarial network enables rapid and robust fluorescence lifetime image analysis in live cells.Communications biology · 2022Article
- Mesoscopic fluorescence lifetime imaging: Fundamental principles, clinical applications and future directions.Journal of biophotonics · 2021Review
- A review of the application of machine learning in molecular imaging.Annals of translational medicine · 2021Review
- Real-time diagnosis and visualization of tumor margins in excised breast specimens using fluorescence lifetime imaging and machine learning.Biomedical optics express · 2020Article
- Intensity-based registration of bright-field and second-harmonic generation images of histopathology tissue sections.Biomedical optics express · 2020Article
- Method for coregistration of optical measurements of breast tissue with histopathology: the importance of accounting for tissue deformations.Journal of biomedical optics · 2019Article
- Calibration of fluorescence imaging for tumor surgical margin delineation: multistep registration of fluorescence and histological images.Journal of medical imaging (Bellingham, Wash.) · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
An important step in establishing the diagnostic potential for emerging optical imaging techniques is accurate registration between imaging data and the corresponding tissue histopathology typically used as gold standard in clinical diagnostics. We present a method to precisely register data acquired with a point-scanning spectroscopic imaging technique from fresh surgical tissue specimen blocks with corresponding histological sections. Using a visible aiming beam to augment point-scanning multispectral time-resolved fluorescence spectroscopy on video images, we evaluate two different markers for the registration with histology: fiducial markers using a 405-nm CW laser and the tissue block's outer shape characteristics. We compare the registration performance with benchmark methods using either the fiducial markers or the outer shape characteristics alone to a hybrid method using both feature types. The hybrid method was found to perform best reaching an average error of 0.78±0.67 mm. This method provides a profound framework to validate diagnostical abilities of optical fiber-based techniques and furthermore enables the application of supervised machine learning techniques to automate tissue characterization.
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