Evidence map›Paper›PMID 29297140›Full record

ArticleNeuroinformatics2018

Embedding Anatomical or Functional Knowledge in Whole-Brain Multiple Kernel Learning Models.

Jessica Schrouff, J M Monteiro, L Portugal, M J Rosa, C Phillips, J Mourão-Miranda

Abstract read
In one paragraph

Article in Neuroinformatics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
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  8. Treatment Response Prediction for Major Depressive Disorder PatientsFrontiers in computational neuroscience · 2022
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  18. All roads lead to the default-mode network-global source of DMN abnormalities in major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jessica SchrouffLaboratory of Behavioral and Cognitive Neuroscience, Stanford University, Stanford, CA, USA. jschrouff@ucl.ac.uk.
J M MonteiroCentre for Medical Image Computing, Department of Computer Science, University College London, London, UK.
L PortugalCentre for Medical Image Computing, Department of Computer Science, University College London, London, UK.
M J RosaCentre for Medical Image Computing, Department of Computer Science, University College London, London, UK.
C PhillipsGIGA Research, University of Liège, Liège, Belgium.
J Mourão-MirandaCentre for Medical Image Computing, Department of Computer Science, University College London, London, UK.

Funding

Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
MORPHOMETRY BIOMEDICAL INFORMATICS RESEARCH NETWORKU24RR021382 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2004 to 2008
$24.1M
STRUCTURE, FUNCTION AND COGNITION IN SCHIZOPHRENIAP50MH071616 · NIMH · WASHINGTON UNIVERSITY · PI BARCH, DEANNA · 2004 to 2008
$11.2M
NEUROMORPHOMETRY IN SCHIZOPHRENIA BY COMPUTER ALGORITHMR01MH056584 · NIMH · WASHINGTON UNIVERSITY · PI CSERNANSKY, JOHN G · 1998 to 2011
$4.2M
Functional-anatomic exploration of cognitive controlR01AG021910 · NIA · WASHINGTON UNIVERSITY · PI BUCKNER, RANDY L · 2005 to 2009
$1.2M
NCRR NIH HHS U24 RR021382NIA NIH HHS P01 AG003991NIA NIH HHS P50 AG005681NIA NIH HHS R01 AG021910NIMH NIH HHS P50 MH071616NIMH NIH HHS R01 MH056584Wellcome Trust
6 · The paper itself

Abstract

Pattern recognition models have been increasingly applied to neuroimaging data over the last two decades. These applications have ranged from cognitive neuroscience to clinical problems. A common limitation of these approaches is that they do not incorporate previous knowledge about the brain structure and function into the models. Previous knowledge can be embedded into pattern recognition models by imposing a grouping structure based on anatomically or functionally defined brain regions. In this work, we present a novel approach that uses group sparsity to model the whole brain multivariate pattern as a combination of regional patterns. More specifically, we use a sparse version of Multiple Kernel Learning (MKL) to simultaneously learn the contribution of each brain region, previously defined by an atlas, to the decision function. Our application of MKL provides two beneficial features: (1) it can lead to improved overall generalisation performance when the grouping structure imposed by the atlas is consistent with the data; (2) it can identify a subset of relevant brain regions for the predictive model. In order to investigate the effect of the grouping in the proposed MKL approach we compared the results of three different atlases using three different datasets. The method has been implemented in the new version of the open-source Pattern Recognition for Neuroimaging Toolbox (PRoNTo).

Indexed as

Machine LearningAlgorithmsBrainDatabases, FactualHumansPattern Recognition, AutomatedSpatial AnalysisAnatomically defined regionsMachine learningMATLAB softwareModel interpretationMultiple Kernel LearningNeuroimaging

Identifiers

PMID29297140
PMCPMC5797202

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.