Evidence map›Paper›PMID 29297113›Full record

ArticleJournal of assisted reproduction and genetics2018

Frozen blastocyst transfer outcomes in immediate versus delayed subsequent cycles following GnRH agonist or hCG triggers.

Leah Kaye, Audrey Marsidi, Puja Rai, Jeffrey Thorne, John Nulsen, Lawrence Engmann, Claudio Benadiva

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Meta-analysis of the embryo freezing transfer interval.Reproductive medicine and biology · 2021
    Review
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  8. Article
  9. Article
  10. To delay or not frozen embryo transfer in freeze-all cycles?Annals of translational medicine · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leah KayeDepartment of Obstetrics and Gynecology, University of Connecticut, 263 Farmington Avenue, Farmington, CT, 06030, USA.
Audrey MarsidiDepartment of Obstetrics and Gynecology, University of Connecticut, 263 Farmington Avenue, Farmington, CT, 06030, USA.
Puja RaiDepartment of Obstetrics and Gynecology, University of Connecticut, 263 Farmington Avenue, Farmington, CT, 06030, USA.
Jeffrey ThorneDepartment of Obstetrics and Gynecology, University of Connecticut, 263 Farmington Avenue, Farmington, CT, 06030, USA.
John NulsenCenter for Advanced Reproductive Services, 2 Batterson Park Road, Farmington, CT, 06032, USA.
Lawrence EngmannCenter for Advanced Reproductive Services, 2 Batterson Park Road, Farmington, CT, 06032, USA.
Claudio BenadivaCenter for Advanced Reproductive Services, 2 Batterson Park Road, Farmington, CT, 06032, USA. benadiva@uchc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study is to analyze clinical pregnancy rates (CPR) and ongoing pregnancy rates (OPR) for frozen embryo transfers (FET) performed with blastocysts in the cycle immediately after GnRH agonist (GnRHa) versus human chorionic gonadotropin (hCG) triggers, with outcomes of delayed FET for comparison.

methodsRetrospective cohort study at a university-affiliated in vitro fertilization (IVF) clinic, including patients undergoing IVF between 2013-16 with a blastocyst FET performed within two menstrual cycles of a previous stimulation cycle and vaginal oocyte retrieval (VOR). FETs included programmed and natural endometrial preparation. Outcome measures were clinical and ongoing pregnancy rates.

resultsCPR and OPR for 344 FET cycles were similar when comparing immediate and delayed transfer overall (crude CPR 67.5 versus 76.5%, p = 0.11; OPR 57.5 versus 66.7%, p = 0.13), and after stratifying by cycles following hCG trigger (OPR 62.5 versus 66.3%, p = 0.61) and GnRHa trigger (OPR 55.6 versus 64.5%, p = 0.17). When considering a number of predictors for OPR, an adjusted odds ratio (OR) of 1.74 [95% CI 1.00-3.03] approached significance in favor of delayed FET.

conclusionsRegardless of trigger modality, patients can be reassured that pregnancy rates with FET are high in immediate and delayed cycles. However, our study suggests a potential benefit in delaying a cycle before proceeding with FET.

Indexed as

CryopreservationAdolescentAdultChorionic GonadotropinEmbryo TransferFemaleFertilization in VitroFreezingGonadotropin-Releasing HormoneHumansMenstrual CycleOocyte RetrievalOocytesPregnancyPregnancy OutcomePregnancy RateChorionic GonadotropinGonadotropin-Releasing HormoneLHRH, Ala(6)-Gly(10)-ethylamide-Frozen embryo transferGonadotropin-releasing hormone/agonistsOvulation induction

Identifiers

PMID29297113
PMCPMC5949104

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.