Evidence map›Paper›PMID 29296972›Full record

ArticleBlood advances2017

Bone marrow transplantation prevents right ventricle disease in the

Kewal Asosingh, Nicholas Wanner, Kelly Weiss, Kimberly Queisser, Liya Gebreab, Biruk Kassa, Eric Stuehr, Brian Graham, Serpil Erzurum

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Myeloid-Derived Suppressor Cells and Pulmonary Hypertension.International journal of molecular sciences · 2018
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kewal AsosinghDepartment of Pathobiology, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH.
Nicholas WannerDepartment of Pathobiology, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH.
Kelly WeissDepartment of Pathobiology, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH.
Kimberly QueisserDepartment of Pathobiology, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH.
Liya GebreabDepartment of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO; and.
Biruk KassaDepartment of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO; and.
Eric StuehrDepartment of Pathobiology, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH.
Brian GrahamDepartment of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO; and.
Serpil ErzurumDepartment of Pathobiology, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH.
Cleveland Clinic Lerner College of Medicine · USUniversity of Colorado Anschutz Medical Campus · US

Funding

NITRIC OXIDE PRODUCTION AND REACTIONS IN THE LUNGR01HL060917 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Serpil C. Erzurum · 1999 to 2026
$6.3M
Investigating paclitaxel treatment in a pre-clinical model of Schistosoma-pulmonary hypertensionR01HL135872 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Brian Barkley Graham · 2017 to 2026
$5.1M
Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2M
Nitric Oxide in Pulmonary HypertensionR37HL060917 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C. · 2009 to 2018
$3.9M
Pulmonary Vascular-Right Ventricular Axis Research ProgramR01HL115008 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C., PRASAD, SATHYAMANGLA V · 2012 to 2016
$3.1M
Role of Th2 CD4 T Cells in Schistosoma Pulmonary HypertensionR03HL133306 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI GRAHAM, BRIAN BARKLEY · 2016 to 2017
$156k
NHLBI NIH HHS R01 HL060917NHLBI NIH HHS R01 HL115008NHLBI NIH HHS R01 HL135872NHLBI NIH HHS R03 HL133306NHLBI NIH HHS R37 HL060917NHLBI NIH HHS U10 HL109250
6 · The paper itself

Abstract

Accumulating evidence shows a causative role for the bone marrow (BM) in the genesis and progression of pulmonary hypertension (PH). Engraftment of BM hematopoietic stem cells from PH patients to mice reproduces the cardiopulmonary pathology of PH. However, it is unknown whether healthy BM can prevent the development of right heart disease.

Identifiers

PMID29296972
PMCPMC5728598
OpenAlexW2596139951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.