Evidence map›Paper›PMID 29296932›Full record

ArticleBlood advances2017

Not just a marker: CD34 on human hematopoietic stem/progenitor cells dominates vascular selectin binding along with CD44.

Dina B AbuSamra, Fajr A Aleisa, Asma S Al-Amoodi, Heba M Jalal Ahmed, Chee Jia Chin, Ayman F Abuelela, Ptissam Bergam, Rachid Sougrat, Jasmeen S Merzaban

Abstract read
In one paragraph

Article in Blood advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Use of Hematopoietic Stem Cells for Heart Failure: A Systematic Review.International journal of molecular sciences · 2024
    Pooled it
  2. Article
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  7. Article
  8. Review
  9. Pigs: Large Animal Preclinical Cancer Models.World journal of oncology · 2024
    Review
  10. Article
  11. Article
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  13. Article
  14. Article
  15. Review
  16. Article
  17. Hematopoietic stem cells and extramedullary hematopoiesis in the lungs.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2023
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dina B AbuSamraCell Migration and Signaling Laboratory, Division of Biological and Environmental Sciences and Engineering, and.ORCID 0000-0002-0974-5362
Fajr A AleisaCell Migration and Signaling Laboratory, Division of Biological and Environmental Sciences and Engineering, and.ORCID 0000-0001-6403-374X
Asma S Al-AmoodiCell Migration and Signaling Laboratory, Division of Biological and Environmental Sciences and Engineering, and.ORCID 0000-0002-8970-3807
Heba M Jalal AhmedCell Migration and Signaling Laboratory, Division of Biological and Environmental Sciences and Engineering, and.ORCID 0000-0003-2172-2494
Chee Jia ChinCell Migration and Signaling Laboratory, Division of Biological and Environmental Sciences and Engineering, and.
Ayman F AbuelelaCell Migration and Signaling Laboratory, Division of Biological and Environmental Sciences and Engineering, and.ORCID 0000-0002-4529-3156
Ptissam BergamImaging and Characterization Core Facility, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Rachid SougratImaging and Characterization Core Facility, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.ORCID 0000-0001-6476-1886
Jasmeen S MerzabanCell Migration and Signaling Laboratory, Division of Biological and Environmental Sciences and Engineering, and.ORCID 0000-0002-7276-2907

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD34 is routinely used to identify and isolate human hematopoietic stem/progenitor cells (HSPCs) for use clinically in bone marrow transplantation, but its function on these cells remains elusive. Glycoprotein ligands on HSPCs help guide their migration to specialized microvascular beds in the bone marrow that express vascular selectins (E- and P-selectin). Here, we show that HSPC-enriched fractions from human hematopoietic tissue expressing CD34 (CD34

Identifiers

PMID29296932
PMCPMC5745127

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.