Evidence map›Paper›PMID 29296903›Full record

ArticleBlood advances2017

Osteomacs interact with megakaryocytes and osteoblasts to regulate murine hematopoietic stem cell function.

Safa F Mohamad, Linlin Xu, Joydeep Ghosh, Paul J Childress, Irushi Abeysekera, Evan R Himes, Hao Wu, Marta B Alvarez, Korbin M Davis, Alexandra Aguilar-Perez and 4 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. 3DACS biomaterials science & engineering · 2026
    Review
  3. Macrophages in Hematopoiesis and Related Blood Diseases.Genomics, proteomics & bioinformatics · 2025
    Review
  4. Exploring CD169Vaccines · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Osteoimmunology in bone malignancies: a symphony with evil.Journal of the National Cancer Center · 2024
    Review
  9. Article
  10. Hematopoietic Stem Cells and Their Niche in Bone Marrow.International journal of molecular sciences · 2024
    Review
  11. Osteoimmunology of Fracture Healing.Current osteoporosis reports · 2024
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Macrophages and Bone Remodeling.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Safa F MohamadDepartment of Microbiology and Immunology.
Linlin XuDepartment of Microbiology and Immunology.
Joydeep GhoshDepartment of Medicine.
Paul J ChildressDepartment of Microbiology and Immunology.
Irushi AbeysekeraDepartment of Orthopaedic Surgery, and.
Evan R HimesDepartment of Orthopaedic Surgery, and.
Hao WuDepartment of Microbiology and Immunology.
Marta B AlvarezDepartment of Orthopaedic Surgery, and.
Korbin M DavisDepartment of Medicine.
Alexandra Aguilar-PerezDepartment of Biomedical and Applied Sciences, School of Dentistry, and.
Jung Min HongDepartment of Biomedical and Applied Sciences, School of Dentistry, and.
Angela BruzzanitiDepartment of Anatomy and Cell Biology, School of Medicine.
Melissa A KacenaDepartment of Orthopaedic Surgery, and.
Edward F SrourDepartment of Microbiology and Immunology.ORCID 0000-0002-6026-6498
Applied Science Private University · JOIndiana University – Purdue University Indianapolis · US

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Jun Wan · 1999 to 2026
$59.3M
Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
REGULATION OF HEMATOPOIETIC CELL PRODUCTIONT32DK007519 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPLAN, MARK H · 1986 to 2020
$7.1M
Regulation of Osteoblast Function by Megakaryocytes: Key Signaling ProteinsR01AR060332 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI BRUZZANITI, ANGELA, KACENA, MELISSA A · 2011 to 2015
$1.7M
NCI NIH HHS P30 CA082709NIAMS NIH HHS R01 AR060332NIDDK NIH HHS T32 DK007519NIDDK NIH HHS U54 DK106846
6 · The paper itself

Abstract

Networking between hematopoietic stem cells (HSCs) and cells of the hematopoietic niche is critical for stem cell function and maintenance of the stem cell pool. We characterized calvariae-resident osteomacs (OMs) and their interaction with megakaryocytes to sustain HSC function and identified distinguishing properties between OMs and bone marrow (BM)-derived macrophages. OMs, identified as CD45

Identifiers

PMID29296903
PMCPMC5728639
OpenAlexW2771234618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.