ArticleBlood advances2017
Low fetal hemoglobin percentage is associated with silent brain lesions in adults with homozygous sickle cell disease.
Article in Blood advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis.BMC medicine · 2020Pooled it
- Hemodynamic provocation with acetazolamide shows impaired cerebrovascular reserve in adults with sickle cell disease.Haematologica · 2019Trial
- Hematopoietic Stem Cell Transplant and Brain Volume Changes in Adults With Sickle Cell Disease.Neurology · 2026Article
- Cerebrovascular and cardiovascular autonomic regulation in sickle cell patients with white matter lesions.European journal of neurology · 2024Article
- Abnormal Neurologic Findings in Patients With Sickle Cell Disease Without a History of Major Neurologic Events.Neurology. Clinical practice · 2024Article
- Variation and impact of polygenic hematologic traits in monogenic sickle cell disease.Haematologica · 2023Article
- Fetal hemoglobin modulates neurocognitive performance in sickle cell anemiaCurrent research in translational medicine · 2022Article
- Progression of central nervous system disease from pediatric to young adulthood in sickle cell anemia.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Genome wide association study of silent cerebral infarction in sickle cell disease (HbSS and HbSC).Haematologica · 2021Article
- Genetic therapies for the first molecular disease.The Journal of clinical investigation · 2021Review
- Fetal hemoglobin in sickle cell anemia.Blood · 2020Review
- Pathophysiology of Sickle Cell Disease.Annual review of pathology · 2019Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silent white matter changes (WMCs) on brain imaging are common in individuals with sickle cell disease (SCD) and are associated with cognitive deficits in children. We investigated the factors predictive of WMCs in adults with homozygous SCD and no history of neurological conditions. Patients were recruited from a cohort of adults with homozygous SCD followed up at an adult sickle cell referral center for which steady-state measurements of biological parameters and magnetic resonance imaging scans of the brain were available. WMCs were rated by consensus, on a validated age-related WMC scale. The prevalence of WMCs was 49% (95% confidence interval [CI], 39%-60%) in the 83 patients without vasculopathy included. In univariable analysis, the patients who had WMCs were more likely to be older (
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.