ArticleBlood advances2017
Depression, quality of life, and medical resource utilization in sickle cell disease.
Article in Blood advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Depression in adults with sickle cell disease: a systematic review of the methodological issues in assessing prevalence of depression.BMC psychology · 2021Pooled it
- The Use of Religion in the Management of Depression in Sickle Cell Disease: A Systematic Review.Journal of religion and health · 2020Pooled it
- The excess costs of depression: a systematic review and meta-analysis.Epidemiology and psychiatric sciences · 2019Pooled it
- Experiences With a Multicomponent Digital Behavioral Pain Management Intervention for Adults With Sickle Cell Disease: Qualitative Analysis of the CaRISMA Trial.JMIR human factors · 2025Trial
- Patient-reported outcomes in sickle cell disease and association with clinical and psychosocial factors: Report from the sickle cell disease implementation consortium.American journal of hematology · 2020Trial
- Feasibility of implementing mobile technology-delivered mental health treatment in routine adult sickle cell disease care.Translational behavioral medicine · 2020Trial
- Association between comorbid depression, antidepressant adherence, and disease-modifying therapy adherence among Texas Medicaid patients with sickle cell disease.Journal of managed care & specialty pharmacy · 2026Article
- Geographic and Temporal Differences in Sickle Cell Disease Hospitalizations in New York State.JAMA network open · 2026Article
- Article
- The Role of Associated Treatment Factors and Mental Health on Transition From Pediatric to Adult Care for Adolescent/Young Adults With Sickle Cell Disease.Pediatric blood & cancer · 2026Article
- Chronic pain in the aging adult with sickle cell disease.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Criterion validity of the functional status and pain assessment scale versus pain and length of stay in hospitalized adults with SCD.Journal of sickle cell disease · 2026Article
- Buprenorphine Is Associated With Lower Home Opioid Use and Acute Care Utilization in Sickle Cell Disease.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2025Article
- Barriers to Care for Adults With Sickle Cell Disease: A Qualitative Descriptive Study.Health expectations : an international journal of public participation in health care and health policy · 2025Article
- Qualitative Assessment of Health-Related Quality of Life Impacts Associated with Sickle Cell Disease in the United States and United Kingdom.Advances in therapy · 2025Article
- Elevated posterior insula glutamate in patients with sickle cell disease.The journal of pain · 2025Article
- Understanding stakeholders' experience with sickle cell disease by social media listening across Europe.Frontiers in genetics · 2025Article
- Barriers and facilitators to implementing a task-sharing mental health intervention for Sickle Cell Disease populations in low- and middle-income countries: a qualitative analysis using the Consolidated Framework for Implementation Research (CFIR).Frontiers in public health · 2025Article
- Recommended measurement protocols for sickle cell disease in the PhenX toolkit: psychosocial factors and social determinants of health.Journal of sickle cell disease · 2025Article
- A 36-Year-Old Black Male With Sickle Cell Disease and Coexisting Psychiatric Comorbidity: Utilizing Open Dialogue Practices to Overcome Stigma and Enhance Patient-Centered Care.Case reports in psychiatry · 2025Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Sickle cell disease (SCD) is a chronic, debilitating disorder. Chronically ill patients are at risk for depression, which can affect health-related quality of life (HRQoL), health care utilization, and cost. We performed an analytic epidemiologic prospective study to determine the prevalence of depression in adult patients with SCD and its association with HRQoL and medical resource utilization. Depression was measured by the Beck Depression Inventory and clinical history in adult SCD outpatients at a comprehensive SCD center. HRQoL was assessed using the SF36 form, and data were collected on medical resource utilization and corresponding cost. Neurocognitive functions were assessed using the CNS Vital Signs tool. Pain diaries were used to record daily pain. Out of 142 enrolled patients, 42 (35.2%) had depression. Depression was associated with worse physical and mental HRQoL scores (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.