Evidence map›Paper›PMID 29296839›Full record

ArticleBlood advances2017

Pak2 regulates myeloid-derived suppressor cell development in mice.

Yi Zeng, Seongmin Hahn, Jessica Stokes, Emely A Hoffman, Monika Schmelz, Maria Proytcheva, Jonathan Chernoff, Emmanuel Katsanis

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. PAK2-driven cytoskeleton-endosome dynamics control macrophage hyperphagia and SIRPA engagement.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. The Role of the p21-Activated Kinase Family in Tumor Immunity.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Bendamustine with Total Body Irradiation Limits Murine Graft-versus-Host Disease in Part Through Effects on Myeloid-Derived Suppressor Cells.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yi ZengDepartment of Pediatrics, Steele Children's Research Center.ORCID 0000-0003-1364-1854
Seongmin HahnDepartment of Pediatrics, Steele Children's Research Center.
Jessica StokesDepartment of Pediatrics, Steele Children's Research Center.
Emely A HoffmanDepartment of Pediatrics, Steele Children's Research Center.
Monika SchmelzDepartment of Pathology, University of Arizona, Tucson, AZ.
Maria ProytchevaDepartment of Pathology, University of Arizona, Tucson, AZ.
Jonathan ChernoffFox Chase Cancer Center, Philadelphia, PA; and.ORCID 0000-0002-4803-7836
Emmanuel KatsanisDepartment of Pediatrics, Steele Children's Research Center.ORCID 0000-0003-1466-6965
University of Arizona · USChildren's Center · USFox Chase Cancer Center · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
Targeting the Kinome in Neurofibromatosis type 1R01CA142928 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI CHERNOFF, JONATHAN · 2010 to 2019
$3.9M
Immunotherapy for Chronic Myelogenous LeukemiaR01CA104926 · NCI · UNIVERSITY OF ARIZONA · PI KATSANIS, EMMANUEL · 2004 to 2013
$2.4M
NCI NIH HHS P30 CA006927NCI NIH HHS R01 CA104926NCI NIH HHS R01 CA142928
6 · The paper itself

Abstract

Myeloid-derived suppressor cells (MDSCs) are CD11b

Identifiers

PMID29296839
PMCPMC5728145
OpenAlexW2761527628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.