Evidence map›Paper›PMID 29296835›Full record

ArticleBlood advances2017

Mutation load and an effector T-cell gene signature may distinguish immunologically distinct and clinically relevant lymphoma subsets.

Christopher R Bolen, Ronald McCord, Sarah Huet, Garrett M Frampton, Richard Bourgon, Fabrice Jardin, Peggy Dartigues, Elizabeth A Punnoose, Edith Szafer-Glusman, Luc Xerri and 3 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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  14. Spatially Informed Gene Signatures for Response to Immunotherapy in Melanoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Christopher R BolenBioinformatics and.
Ronald McCordOncology Biomarker Development, Genentech, South San Francisco, CA.
Sarah HuetLaboratory of Hematology, Lyon-Sud Hospital Center, Pierre-Benite, France.
Garrett M FramptonFoundation Medicine, Inc, Cambridge, MA.
Richard BourgonBioinformatics and.
Fabrice JardinHenri Becquerel Center, Rouen, France.
Peggy DartiguesGustave Roussy Institute, Villejuif, France; and.
Elizabeth A PunnooseOncology Biomarker Development, Genentech, South San Francisco, CA.
Edith Szafer-GlusmanOncology Biomarker Development, Genentech, South San Francisco, CA.
Luc XerriDepartment of Bio-Pathology, Hematology, and Tumor Immunology, and.
Pierre SujobertLaboratory of Hematology, Lyon-Sud Hospital Center, Pierre-Benite, France.
Gilles SallesLaboratory of Hematology, Lyon-Sud Hospital Center, Pierre-Benite, France.
Jeffrey M VenstromOncology Biomarker Development, Genentech, South San Francisco, CA.
Inserm · FRFoundation Medicine (United States)Hôpital Lyon Sud · FRInstitut Gustave Roussy · FRInstitut Paoli-Calmettes · FRLaboratoire National Henri Becquerel · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identifying follicular lymphoma (FL) patients with preexisting antitumor immunity will inform precision medicine strategies for novel cancer immunotherapies. Using clinical and genomic data from 249 FL patients, we determined the clinical impact of mutation load and an effector T-cell (T

Identifiers

PMID29296835
PMCPMC5728140
OpenAlexW2756980680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.